Biomarkers of Traumatic Brain Injury With Tbit System

NCT ID: NCT04107662

Last Updated: 2024-04-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

740 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-12-01

Study Completion Date

2025-05-30

Brief Summary

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A prospective, multi-center, non-randomized, pivotal study to assess the safety and efficacy of the Tbit™ System to aid in patient evaluation, suspected of traumatic brain injury, as adjunct companion test to radiologic standard of care, Cranial Computerized Tomography (CCT).

Detailed Description

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Conditions

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Brain Injuries, Traumatic

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Traumatic Brain Injury

Tbit system

Intervention Type DEVICE

Suspected traumatic brain injury with head CT

Interventions

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Tbit system

Suspected traumatic brain injury with head CT

Intervention Type DEVICE

Other Intervention Names

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Head CT scan and blood draw within 12 hours of injury

Eligibility Criteria

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Inclusion Criteria

* At least 18 years of age
* Presents to the Emergency Department with suspected traumatic brain injury
* Prescribed a non-contrast CCT as part of routine emergency care within 24 hours from injury
* Blood sample collected for Tbit™ System within 12 hours of injury
* Willing and able to provide informed consent or obtain consent from legal authorized representative (LAR)

Exclusion Criteria

* Suspect of ischemic or hemorrhagic stroke with subsequent incidental trauma based on ED examination
* Subject suspect of need of craniotomy for the acute trauma for this event
* External signs compatible with a depressed skull fracture based on ED exam
* Subject requiring administration of blood transfusion after injury and prior to study blood draw
* Subject for whom timing of injury is unable to be estimated within 1 hour of certainty
* Subject with a condition precluding entry into the CT scanner
* Subject who had neurodegenerative disease or other neurological disorder including dementia, Parkinson's disease, multiple sclerosis, seizures, brain tumors, stroke or TIA within the last 30 days, or history of neurosurgery
* Known or suspected to be pregnant
* Prisoner or under incarceration
* Participating in another clinical research study prior to this study completion
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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BioDirection Inc

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jerika Acosta, BSc

Role: STUDY_DIRECTOR

Medicept Inc.

Central Contacts

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Adelina A Paunescu, PhD

Role: CONTACT

7815268152

Travis Jones, BSc

Role: CONTACT

6783207670

Other Identifiers

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BDI-TBIT-03

Identifier Type: -

Identifier Source: org_study_id

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