Type 2 Diabetes Affect Exercise Induced Improvement in Insulin Sensitivity

NCT ID: NCT02745613

Last Updated: 2020-01-30

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 24 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-04-30
• Study Completion Date: 2019-05-31

Brief Summary

This study investigates weather a family history of type 2 diabetes affects exercise induced improvements in insulin sensitivity in the hispanic population

Detailed Description

A family history of T2D (FH+) is a risk factor for developing insulin resistance (which precedes T2D) and T2D (Ryder et al., 2003). Exercise training on the other hand has been shown to improve insulin sensitivity and is highly effective to prevent/manage T2D. However it is not known if early signs of insulin resistance appear before being clinically diagnosed and if the benefits of exercise which prevent/cure T2D, are limited to the offspring of Hispanic T2D parents. Therefore, the proposed study will determine 1) if normoglycemic (normal blood glucose) offspring of T2D parents are insulin resistant, using the gold standard method to measure insulin sensitivity and metabolic flexibility (ability to switch between carbohydrate and fat oxidation) 2) if 8 weeks of exercise training improves insulin sensitivity and metabolic flexibility to the same extent in FH+ compared to normoglycemic offspring of parents without any history of T2D (FH-) and 3) if 8 weeks of exercise training will change the blood, lipid and molecular profiles relevant to insulin sensitivity to same extent in FH+ compared to offspring of parents without family history of T2D (FH-).

Conditions

Insulin Sensitivity/Resistance

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: DOUBLE

Study Groups

Family history of T2D

The participants will undergo 8 weeks of combined exercise

Group Type: EXPERIMENTAL

8 weeks of combined exercise intervention

Intervention Type: OTHER

The subjects will undergo an 8 week combined exercise intervention

No Family history of T2D

The participants will undergo 8 weeks of combined exercise

Group Type: EXPERIMENTAL

8 weeks of combined exercise intervention

Intervention Type: OTHER

The subjects will undergo an 8 week combined exercise intervention

Interventions

8 weeks of combined exercise intervention

The subjects will undergo an 8 week combined exercise intervention

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 18 ≤ Age ≤ 40 years
• 18 ≤ BMI ≤ 30 kg/m2
• Both parents are Mexican/Mexican-American)
• Sedentary lifestyle
• Less than 60 minutes/wk. of structured exercise
• Physical activity level ≤ 1.4

Exclusion Criteria

• Evidence of significant cardiovascular disease or diabetes
• A fasting blood glucose ≥100 mg/dL
• Screening blood pressure >140/90
• Hyperlipidemia
• Use of drugs affecting energy metabolism or body weight
• Excess alcohol, drug abuse, and smoking
• Eating disorder or eating attitudes interfering with study
• Unwillingness to be abide by randomization

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Texas, El Paso

OTHER

Sponsor Role: lead

Responsible Party

Sudip Bajpeyi

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Sudip Bajpeyi, PhD.

Role: PRINCIPAL_INVESTIGATOR

University of Texas, El Paso

Locations

University of Texas at El Paso

El Paso, Texas, United States

Countries

United States

Other Identifiers

755513-1

Identifier Type: -

Identifier Source: org_study_id