The Influence of Cortical Bone Perforation on Guided Bone Regeneration in Humans
NCT ID: NCT02741752
Last Updated: 2016-04-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
14 participants
INTERVENTIONAL
2015-01-31
2016-01-31
Brief Summary
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Detailed Description
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Methods: Fourteen patients (mean age: 52) who were in need of dental implants at areas with osseous defects in the mandible were selected. In the test group (n=7), alveolar cortical bone at the area of regeneration was perforated using a #2 high speed round bur. No decortication of cortical bone was performed in the control group (n=7). Subsequently, defects were augmented by guided bone regeneration using resorbable membrane and bovine bone. After a healing period of 7 months, implant sites were created and trephine cores harvested for histological and histomorphometric analysis of the grafted areas.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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test group
decortication group
Decortication
cortical bone perforation
control
without decortication
No interventions assigned to this group
Interventions
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Decortication
cortical bone perforation
Eligibility Criteria
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Inclusion Criteria
* Inclusion criteria were presence of atrophic mandibular ridges with bucco-lingual width ranging between 2-5 mm, as measured on serial sections of a computerized axial tomography (CAT) scan.
Exclusion Criteria:
* Exclusion criteria included patients with diabetes, osteoporosis or other metabolic disorders, smokers, pregnant patients and patients who had any systemic or local factors that would inhibit normal wound healing process.
25 Years
72 Years
ALL
Yes
Sponsors
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Mashhad University of Medical Sciences
OTHER
Responsible Party
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seyedamir Danesh Sani
Principal Investigator, postgraduate resident
Other Identifiers
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97345
Identifier Type: -
Identifier Source: org_study_id
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