Assessment of Ridge Preservation Using Moldable Beta-tricalcium Phosphate Bone Grafting System

NCT ID: NCT02702609

Last Updated: 2020-10-22

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-08-02

Study Completion Date

2019-08-19

Brief Summary

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Randomized Controlled study to compare the effectiveness of two different treatment approaches using a new moldable beta-tricalcium phosphate(TCP) bone graft material in ridge preservation of an atraumatic extraction socket site compared to allograft with collagen plug.

Detailed Description

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Conditions

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Dental Implants Alveolar Ridge Preservation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Moldable beta-TCP grafting system

Device: easy-graft CLASSIC (beta-Tricalcium Phosphate)

Group Type EXPERIMENTAL

easy-graft CLASSIC

Intervention Type DEVICE

easy-graft will be grafted to a single extraction socket to preserve the ridge dimension for future implant placement.

Allograft

Device: Freeze-Dried Bone Allograft (FDBA) with collagen plug

Group Type ACTIVE_COMPARATOR

FDBA with collagen plug

Intervention Type DEVICE

FDBA will be grafted to a single extraction socket and covered by collagen plug to preserve the ridge dimension for future implant placement.

Interventions

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easy-graft CLASSIC

easy-graft will be grafted to a single extraction socket to preserve the ridge dimension for future implant placement.

Intervention Type DEVICE

FDBA with collagen plug

FDBA will be grafted to a single extraction socket and covered by collagen plug to preserve the ridge dimension for future implant placement.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Provision of informed consent
* At least 18 years old
* In need of one posterior tooth, excluding third molar molars, planned for extraction and replacement with a dental implant (If the subject requires two adjacent socket preservation, they can still be enrolled in the study but only one site will be used for the study)
* Intact ridge as verified with cone-beam CT scan
* At least one natural tooth adjacent to the study site present.

Exclusion Criteria

* Insufficient interocclusal space to allow for implant supported prosthesis
* Dehiscence or fenestration identified at the time of reviewing CBCT.
* Non-treated caries or uncontrolled periodontal disease present affecting the teeth in adjacent to study teeth.
* Any of natural teeth adjacent to the study site presents active periapical endodontic lesion ("active periapical endodontic lesion" will be determined per consultation by endodontics specialist).
* Adjacent tooth (mesial and distal) to study site was extracted within last 6 months
* Adjacent teeth (or tooth) to study site with significant soft tissue loss
* Smoker using more than 10 cigarettes or equivalent per day
* Smokeless tobacco use or e-cigarette use
* Current alcohol or drug abuser
* Systemic or local disease or condition that would compromise post-operative healing and/or osseointegration e.g. uncontrolled diabetes
* Need for systemic corticosteroids or any other medication that would influence post-operative healing and/or osseointegration
* Pregnancy, as indicated by positive serum human chorionic gonadotropin (HCG) test result.
* Unable or unwilling to return for follow-up visits for a period of 5 months
* Unlikely to be able to comply with study procedures according to Investigators judgement
* Subject in other clinical trials
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sunstar Americas

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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The University of Iowa College of Dentistry

Iowa City, Iowa, United States

Site Status

University of Maryland School of Dentistry

Baltimore, Maryland, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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CLP-2015-12-17-1

Identifier Type: -

Identifier Source: org_study_id

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