Effect of Ca2+ Ionophore on Embryonic Development and Clinical Outcome in Cases With Previous Fertilization Arrest
NCT ID: NCT02683031
Last Updated: 2016-08-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
50 participants
INTERVENTIONAL
2014-05-31
2017-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Without Ca2+ ionophore
Patients with previous incomplete ICSI cycle due to fertilization arrest were counseled to underwent a subsequent conventional ICSI cycle.
No interventions assigned to this group
With Ca2+ ionophore
Patients with previous incomplete ICSI cycle due to fertilization arrest were counseled to underwent a subsequent ICSI cycle combined with artificial oocyte activation using Ca2+ ionophore.
Ca2+ ionophore
Ca2+ ionophore is a chemical agent used to perform oocyte activation after ICSI. It showed effective treatment to get better fertilization, pregnancy, and healthy livebirth in cases with total or partial fertilization failure.
Interventions
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Ca2+ ionophore
Ca2+ ionophore is a chemical agent used to perform oocyte activation after ICSI. It showed effective treatment to get better fertilization, pregnancy, and healthy livebirth in cases with total or partial fertilization failure.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* ovarian stimulation with the GnRH agonist and recombinant FSH in a long protocol.
Exclusion Criteria
20 Years
39 Years
FEMALE
No
Sponsors
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Benha University
OTHER
TopLab Company for ART Laboratories Consultation and Training
OTHER
Responsible Party
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Yasmin Magdi
Senior clinical embryologist
Principal Investigators
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Yasmin Magdi, M.Sc
Role: PRINCIPAL_INVESTIGATOR
Dar Almaraa fertility and gynacology center
Mona M. Awady, MD
Role: STUDY_CHAIR
Department of Community Medicine, Faculty of Medicine, Benha University, Benha, Egypt
Locations
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Ahmed el-Damen
Cairo, , Egypt
Countries
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Central Contacts
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Facility Contacts
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Ahmed El-Damen
Role: primary
References
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Ebner T, Koster M, Shebl O, Moser M, Van der Ven H, Tews G, Montag M. Application of a ready-to-use calcium ionophore increases rates of fertilization and pregnancy in severe male factor infertility. Fertil Steril. 2012 Dec;98(6):1432-7. doi: 10.1016/j.fertnstert.2012.07.1134. Epub 2012 Aug 24.
Ebner T, Montag M; Oocyte Activation Study Group; Montag M, Van der Ven K, Van der Ven H, Ebner T, Shebl O, Oppelt P, Hirchenhain J, Krussel J, Maxrath B, Gnoth C, Friol K, Tigges J, Wunsch E, Luckhaus J, Beerkotte A, Weiss D, Grunwald K, Struller D, Etien C. Live birth after artificial oocyte activation using a ready-to-use ionophore: a prospective multicentre study. Reprod Biomed Online. 2015 Apr;30(4):359-65. doi: 10.1016/j.rbmo.2014.11.012. Epub 2014 Dec 9.
Darwish E, Magdi Y. A preliminary report of successful cleavage after calcium ionophore activation at ICSI in cases with previous arrest at the pronuclear stage. Reprod Biomed Online. 2015 Dec;31(6):799-804. doi: 10.1016/j.rbmo.2015.08.012. Epub 2015 Aug 28.
Other Identifiers
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#0010010
Identifier Type: -
Identifier Source: org_study_id
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