Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

84 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-11-30

Study Completion Date

2024-06-30

Brief Summary

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The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment. The current approach is novel in that it contains a prophylaxis component in which the investigators attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific in its targeting of word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in dementia. One set of participants with PPA will receive practice with picture naming in two conditions: viewing the picture and repeating the name; and viewing the picture with its written name, plus reading and writing the name. Another set of participants with PPA or Alzheimer's Disease will be trained in two different conditions: learning about the word's semantic features (meaning); and learning about the word's lexical features (letters and sounds). Naming of pictures trained in each of these conditions will be compared, at three time intervals post-training, with naming of pictures tested before the study but never trained. It is predicted that the pairing of the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simple practice viewing the picture and repeating the name. Furthermore, it is predicted that participants who have difficulty understanding concepts will be more likely to respond to semantic treatment, while participants who have difficulty connecting words with concepts will be more likely to respond to lexical treatment.

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Detailed Description

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Conditions

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Aphasia, Primary Progressive Anomia Alzheimer Disease

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SEQUENTIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Phonological, Orthographic, Untrained

Group Type EXPERIMENTAL

Phonological

Intervention Type BEHAVIORAL

This treatment involves picture viewing and word repetition.

Orthographic

Intervention Type BEHAVIORAL

This treatment involves picture viewing, reading, and writing.

Untrained

Intervention Type BEHAVIORAL

These words are not trained during the treatment phase.

Semantic, Lexical, Untrained

Group Type EXPERIMENTAL

Semantic

Intervention Type BEHAVIORAL

This treatment involves learning about the semantic features (meaning) of each trained word.

Lexical

Intervention Type BEHAVIORAL

This treatment involves learning about the lexical features (letters and sounds) of each trained word.

Untrained

Intervention Type BEHAVIORAL

These words are not trained during the treatment phase.

Interventions

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Phonological

This treatment involves picture viewing and word repetition.

Intervention Type BEHAVIORAL

Orthographic

This treatment involves picture viewing, reading, and writing.

Intervention Type BEHAVIORAL

Semantic

This treatment involves learning about the semantic features (meaning) of each trained word.

Intervention Type BEHAVIORAL

Lexical

This treatment involves learning about the lexical features (letters and sounds) of each trained word.

Intervention Type BEHAVIORAL

Untrained

These words are not trained during the treatment phase.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of Primary Progressive Aphasia (PPA; including Frontotemporal Dementia, Semantic Dementia, or a similar condition) or Diagnosis of Alzheimer's Disease
* At least 10 years of education
* Ability to follow spoken instructions
* Medically stable
* First language is English, or fluent in English since childhood
* Willing to participate over a period of two years