The Effects of Acute Caloric Deprivation on Odour Identification and Food Reward

NCT ID: NCT02653378

Last Updated: 2016-01-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 10 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2009-11-30
• Study Completion Date: 2012-03-31

Brief Summary

The purpose of this study is to determine how the modality of energy depletion can differently impact appetite hormones, ad libitum food intake, food hedonics, and olfaction.

Detailed Description

The objectives of the current randomized controlled study were to examine how the modality of an acute 3 day isocaloric -25% energy depletion by dieting alone or by aerobic exercise alone differently impacts appetite and appetite-related hormones, ad libitum energy intake (EI), food hedonics and food reward, and olfaction. It was hypothesized that independent of modality of depletion, that relative to the control, there would be increased ad libitum feeding and food reward, improvements in smell performance, and a decline in fasting leptin and increase in fasting total ghrelin. It was also hypothesized that the increased food reward would prove to be a predictor of ad libitum EI and that relative to the depletion by aerobic exercise alone, the depletion by diet alone would produce greater compensatory increases in appetite, ad libitum EI, and food reward.

Statistics

To test for differences in body weight, plasma hormone concentrations, relative-reinforcing value of food (RRVF), and olfaction across each condition of the study, repeated measures ANOVA controlling for day 1 as a covariate was employed. Pairwise comparisons at day 4 using Sidak adjustment to account for multiple comparisons are reported when the ANOVA was significant. One way repeated measures ANOVAs with Sidak adjustments for multiple comparisons were used to test for differences in variables measured only at day 4: body composition (fat mas, %Fat, and fat free mass), appetite, palatability, and ad libitum EI.

Conditions

Olfaction; Diet; Exercise; Energy Depletion; Food Hedonics; Food Reward

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

DIET ARM

A 25% energy depletion (daily for 3 days) induced by reducing the amount of energy intake that would otherwise keep the individual in energy balance.

Group Type: ACTIVE_COMPARATOR

DIET

Intervention Type: BEHAVIORAL

25% Energy Depletion by Diet only for 3 Days

EX ARM

A 25% energy depletion (daily for 3 days) induced by performing aerobic exercise at 50% of V02max.

Group Type: ACTIVE_COMPARATOR

EX

Intervention Type: BEHAVIORAL

25% Energy Depletion by Exercise only for 3 Days

Interventions

DIET

25% Energy Depletion by Diet only for 3 Days

Intervention Type: BEHAVIORAL

EX

25% Energy Depletion by Exercise only for 3 Days

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• Free from any illness that could influence outcome of the experiment
• Weight-stable for >6months
• aged between 18-40 years

Exclusion Criteria

• diabetic
• smoker
• medication

• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Ottawa

OTHER

Sponsor Role: lead

Responsible Party

Eric Doucet

Professor of Human Kinetics

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Eric Doucet, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Ottawa

References

McNeil J, Lamothe G, Cameron JD, Riou ME, Cadieux S, Lafreniere J, Goldfield G, Willbond S, Prud'homme D, Doucet E. Investigating predictors of eating: is resting metabolic rate really the strongest proxy of energy intake? Am J Clin Nutr. 2017 Nov;106(5):1206-1212. doi: 10.3945/ajcn.117.153718. Epub 2017 Sep 6.

Reference Type: DERIVED

PMID: 28877891 (View on PubMed)

Cameron JD, Goldfield GS, Riou ME, Finlayson GS, Blundell JE, Doucet E. Energy depletion by diet or aerobic exercise alone: impact of energy deficit modality on appetite parameters. Am J Clin Nutr. 2016 Apr;103(4):1008-16. doi: 10.3945/ajcn.115.115584. Epub 2016 Feb 17.

Reference Type: DERIVED

PMID: 26888712 (View on PubMed)

Other Identifiers

H09-09-03

Identifier Type: -

Identifier Source: org_study_id