Investigating Physiological Adaptations to Weight Loss

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

50 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-02-29

Study Completion Date

2009-12-31

Brief Summary

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The purpose of this study is to examine the effect of diet-induced weight loss on the levels of circulating nutrients and hormones which are involved in feelings of hunger and satiety.

Detailed Description

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Conditions

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Obesity

Keywords

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Weight loss Weight maintenance

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Interventions

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Optifast VLCD

Meal replacement, three times daily for 8 weeks

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* males and post-menopausal females
* aged over 18 years
* BMI 27-40kg/m2
* weight-stable

Exclusion Criteria

* major comorbid medial condition (including diabetes)
* taking medications known to affect weight
* smoking

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Priya Sumithran

Clinical research fellow

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Heidelberg Repatriation Hospital

Melbourne, Victoria, Australia

Site Status

Countries

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Australia

References

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Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J. Long-term persistence of hormonal adaptations to weight loss. N Engl J Med. 2011 Oct 27;365(17):1597-604. doi: 10.1056/NEJMoa1105816.

Reference Type DERIVED

PMID: 22029981 (View on PubMed)

Other Identifiers

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HP 508920

Identifier Type: -

Identifier Source: org_study_id