Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis

NCT ID: NCT02641964

Last Updated: 2021-01-25

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 350 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-11-30
• Study Completion Date: 2021-01-31

Brief Summary

Try to collect about 350 cases of acute necrotizing pancreatitis at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command. Then the investigators studied the incidence and the risk factors of ARDS in patients with acute necrotizing pancreatitis.

Detailed Description

Using electronic patient data monitoring systems, the investigators reviewed all patients with a diagnosis of pancreatitis admitted to surgical wards or ICUs at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command from January 1, 2009, to October 31, 2015. Inclusion criteria were adult patients (age >18 years) with acute necrotizing pancreatitis. Exclusion criteria were as follows : 1) lack of radiologic evidence to diagnose acute necrotizing pancreatitis, 2) presence of ARDS before admission to hospitals, 3) unable to partner treatment and leaving hospitals, 4) transferring to the investigators' hospitals after treatment, 5) missing other necessary data, and 6) pregnancy.

For enrolled patients, general clinical characteristics were collected. Patients were categorized into two groups according to ARDS or non-ARDS, and the differences of these characteristics between two groups were evaluated. Potential risk factors were collected and studied by using multiple logistic regression analysis.

Conditions

Acute Necrotizing Pancreatitis; Acute Respiratory Distress Syndrome

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: RETROSPECTIVE

Study Groups

ARDS group

patients with acute necrotizing pancreatitis complicated by ARDS

No interventions assigned to this group

non-ARDS group

acute necrotizing pancreatitis patients without ARDS

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Adult patients (age >18 years) with acute necrotizing pancreatitis

Exclusion Criteria

• lack of radiologic evidence to diagnose acute necrotizing pancreatitis,
• presence of ARDS before admission to hospitals,
• unable to partner treatment and leaving hospitals,
• transferring to the investigators' hospitals after treatment,
• missing other necessary data,
• pregnancy.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Nanjing Medical University

OTHER

Sponsor Role: lead

Responsible Party

Bin He

Emergency department physician

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Bin He, Master

Role: STUDY_DIRECTOR

Nanjing Medical University

Other Identifiers

JSSRMYY-HB-1

Identifier Type: -

Identifier Source: org_study_id