Clinical Empirical Research of ARDS

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-18

Study Completion Date

2026-06-01

Brief Summary

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According to the ARDS Berlin definition, patients with severe concurrent invasive mechanical ventilation were selected, and clinical data and prognosis were collected. Samples such as blood and balf were collected for analysis based on changes in the condition.

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Detailed Description

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Conditions

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Invasive Mechanical Ventilation ARDS

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Eligibility Criteria

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Inclusion Criteria

1. Patients who meet the Berlin definition of ARDS and require invasive mechanical ventilation. ARDS diagnostic criteria: according to the Berlin definition, Chest radiograph shows patchy shadows in the lungs; Respiratory failure cannot be completely caused by heart failure or excessive fluid infusion
2. ARDS onset ≤ 3 days when included in the study
3. Patient PaO2/FiO2 ≤ 200mmHg when included in the study

Exclusion Criteria

* 1\) Patients with intracranial hypertension, pleural fistula, pneumothorax, HIV, HBV, HCV

2\) Age\>85 years old or\<18 years old

3\) Pregnant patients

4\) Severe hemodynamic instability (vasopressor increase\>30% in the first 6 hours, or Norepinephrine\>0.5 mg kg/min)

5\) Patients unable to perform EIT ventilation and/or perfusion testing (unable to perform internal jugular vein catheterization, Hypernatremia, chest malformation, active implant device, unstable spinal injury or fracture, skin lesions opposite the EIT monitoring area)

6\) Patients with abnormal esophageal anatomical structure and inability to indwelling gastric tubes

7\) Disagreement for inclusion in this study

Minimum Eligible Age

18 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No