Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
41 participants
INTERVENTIONAL
2011-01-31
2017-09-30
Brief Summary
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The investigators will also examine, in a group of normal adults, repeatability of the agreement between the two devices, and whether the agreement is affected by a change in tidal breathing parameters.
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Detailed Description
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Spirometry is the gold standard for measuring lung function in both clinical support and research roles. Modern spirometers are high precision, reliable instruments enabling a large numbers of parameters relating to lung volumes and the rate of emptying the lungs during a forced expiration to be measured. The most common and accurate method to measure the patient's forced expiration is via pneumotachograph which measures the flow of air through a mouthpiece and integrates the signal to derive the volume expired.
Structured Light Plethysmography (SLP) system that measures changes of the chest and abdominal wall movement during breathing by modelling the thorax and abdominal surface defined by a projected structured light pattern which enables a grid of virtual parts to be formed, the movement of which is recorded by digital cameras. SLP provides non-contact assessment to provide lung function data utilising structured light technologies and enhanced imaging processing.
In this study direct comparison will be made of measurements recorded simultaneously using the two measuring devices in children and adults.
To examine repeatability of the agreement between tidal breathing parameters measured by two techniques, repeated measurements will be performed in each of a group of normal adult subjects. The investigators will also examine whether the agreement is affected by a change in tidal breathing parameters. To obtain a change in tidal breathing parameters, measurements will be recorded during resting spontaneous breathing and after a period of exercise to elevate Respiratory Rate.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
NONE
Study Groups
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Breathing Sequence
Simultaneous measurement using Structured Light Plethysmography and Pneumotachograph Spirometry during a period of tidal breathing followed by a forced respiratory manoeuvre. This sequence is repeated twice.
Structured Light Plethysmography
Non contact device that uses light to record displacement of the anterior thorax and abdomen region
Pneumotachograph Spirometry
Device that measures airflow at the mouth using a mouthpiece
Agreement and repeatability Breathing Sequence
Simultaneous measurement using Structured Light Plethysmography and Pneumotachograph Spirometry during a period of tidal breathing. This sequence is repeated one further time at rest, and once further time after an exercise test to elevate respiratory rate.
Structured Light Plethysmography
Non contact device that uses light to record displacement of the anterior thorax and abdomen region
Pneumotachograph Spirometry
Device that measures airflow at the mouth using a mouthpiece
Interventions
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Structured Light Plethysmography
Non contact device that uses light to record displacement of the anterior thorax and abdomen region
Pneumotachograph Spirometry
Device that measures airflow at the mouth using a mouthpiece
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* For the Healthy Normals group, any adult between 18 and 80 years with no current or previous respiratory condition.
Exclusion Criteria
* chest surgery within 4 weeks
* Haemoptysis of unknown origin the (forced expiratory manoeuvre may aggravate the underlying condition)
* Pneumothorax
* Unstable respiratory or cardiovascular status (forced expiratory manoeuvre may worsen angina or cause changes in blood pressure) or recent myocardial infarction or pulmonary embolus
* Recent eye surgery
* Presence of an acute disease process that might interfere with test performance (e.g. Nausea, vomiting)
6 Years
80 Years
ALL
Yes
Sponsors
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Cambridge University Hospitals NHS Foundation Trust
OTHER
University of Cambridge
OTHER
Pneumacare Ltd
INDUSTRY
Responsible Party
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Principal Investigators
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Karl Sylvester, PhD
Role: PRINCIPAL_INVESTIGATOR
Addenbrookes University Hospitals NHS Trust
Locations
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Cambridge University Hospitals Foundation Trust
Cambridge, Cambridgeshire, United Kingdom
Countries
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References
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Stocks J, Godfrey S, Beardsmore C, Bar-Yishay E, Castile R; ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Plethysmographic measurements of lung volume and airway resistance. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/ American Thoracic Society. Eur Respir J. 2001 Feb;17(2):302-12. doi: 10.1183/09031936.01.17203020.
Bates JH, Schmalisch G, Filbrun D, Stocks J. Tidal breath analysis for infant pulmonary function testing. ERS/ATS Task Force on Standards for Infant Respiratory Function Testing. European Respiratory Society/American Thoracic Society. Eur Respir J. 2000 Dec;16(6):1180-92. doi: 10.1034/j.1399-3003.2000.16f26.x.
Ferrigno G, Carnevali P, Aliverti A, Molteni F, Beulcke G, Pedotti A. Three-dimensional optical analysis of chest wall motion. J Appl Physiol (1985). 1994 Sep;77(3):1224-31. doi: 10.1152/jappl.1994.77.3.1224.
Cala SJ, Kenyon CM, Ferrigno G, Carnevali P, Aliverti A, Pedotti A, Macklem PT, Rochester DF. Chest wall and lung volume estimation by optical reflectance motion analysis. J Appl Physiol (1985). 1996 Dec;81(6):2680-9. doi: 10.1152/jappl.1996.81.6.2680.
Other Identifiers
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CIP01/0010
Identifier Type: -
Identifier Source: org_study_id
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