Infraclavicular Perineural Dexmedetomidine

NCT ID: NCT02550782

Last Updated: 2017-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2015-12-31

Brief Summary

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Infraclavicular block is one of the peripheral nerve block used in upper extremity surgery. Adjuvant agents are used in peripheral nerve blocks to increase the duration and block quality. We investigated that the effects of patient-controlled perineural dexmedetomidine application on postoperative analgesia.

Detailed Description

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Conditions

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The Analgesic Effects

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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perineural bupivacaine

patient-controlled infraclavicular perineural bupivacaine

(1% bupivacaine (marcaine), 5 ml bolus dose, infusion rate of 5 ml / h, lockout time 1 hour)

Group Type ACTIVE_COMPARATOR

Bupivacaine

Intervention Type DRUG

patient- controlled infraclavicular perineural marcaine infusion

Dexmedetomidine

Intervention Type DRUG

patient- controlled infraclavicular perineural marcaine with dexmedetomidine infusion

perineural dexmedetomidine

patient-controlled infraclavicular perineural dexmedetomidine

(1% bupivacaine + 200 mic / 100cc dexmedetomidine, 5 ml bolus dose, infusion rate of 5 ml / h, lockout time 1 hour)

Group Type EXPERIMENTAL

Bupivacaine

Intervention Type DRUG

patient- controlled infraclavicular perineural marcaine infusion

Dexmedetomidine

Intervention Type DRUG

patient- controlled infraclavicular perineural marcaine with dexmedetomidine infusion

Interventions

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Bupivacaine

patient- controlled infraclavicular perineural marcaine infusion

Intervention Type DRUG

Dexmedetomidine

patient- controlled infraclavicular perineural marcaine with dexmedetomidine infusion

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* be undergoing distal upper extremity surgery
* Be between 18-65 years
* to agree to participate in research

Exclusion Criteria

* allergy to dexmedetomidine
* AV block or bradycardia
* being serious cardiac - liver - kidney function disorders
* Being coagulopathy
* neuropathy in the upper extremity
* adrenoceptor agonists or antagonists use
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Erzincan University

OTHER

Sponsor Role collaborator

Cukurova University

OTHER

Sponsor Role lead

Responsible Party

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ILKE KUPELI

Anaesthesiology and reanimation

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Erzincan Üniversity

Erzincan, Merkez, Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Latifzai K, Sites BD, Koval KJ. Orthopaedic anesthesia - part 2. Common techniques of regional anesthesia in orthopaedics. Bull NYU Hosp Jt Dis. 2008;66(4):306-16.

Reference Type BACKGROUND
PMID: 19093908 (View on PubMed)

Mariano ER, Loland VJ, Sandhu NS, Bishop ML, Lee DK, Schwartz AK, Girard PJ, Ferguson EJ, Ilfeld BM. Comparative efficacy of ultrasound-guided and stimulating popliteal-sciatic perineural catheters for postoperative analgesia. Can J Anaesth. 2010 Oct;57(10):919-26. doi: 10.1007/s12630-010-9364-7. Epub 2010 Aug 11.

Reference Type BACKGROUND
PMID: 20700680 (View on PubMed)

Gray AT, Collins AB, Schafhalter-Zoppoth I. An introduction to femoral nerve and associated lumbar plexus nerve blocks under ultrasonic guidance. Tech Reg Ananesth Pain Man. 2004;8:155-63.

Reference Type BACKGROUND

Greengrass R, Steele S, Moretti G. Peripheral nerve blocks. In: Raj PP, editor. Textbook of regional anesthesia. New York: Churchill Livingstone; 2002. p. 325-77.

Reference Type BACKGROUND

White PF, Issioui T, Skrivanek GD, Early JS, Wakefield C. The use of a continuous popliteal sciatic nerve block after surgery involving the foot and ankle: does it improve the quality of recovery? Anesth Analg. 2003 Nov;97(5):1303-1309. doi: 10.1213/01.ANE.0000082242.84015.D4.

Reference Type BACKGROUND
PMID: 14570643 (View on PubMed)

di Benedetto P, Casati A, Bertini L, Fanelli G, Chelly JE. Postoperative analgesia with continuous sciatic nerve block after foot surgery: a prospective, randomized comparison between the popliteal and subgluteal approaches. Anesth Analg. 2002 Apr;94(4):996-1000, table of contents. doi: 10.1097/00000539-200204000-00041.

Reference Type BACKGROUND
PMID: 11916811 (View on PubMed)

Svediene S, Andrijauskas A, Ivaskevicius J, Saikus A. The efficacy comparison of on-demand boluses with and without basal infusion of 0.1 % bupivacaine via perineural femoral catheter after arthroscopic ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2013 Mar;21(3):641-5. doi: 10.1007/s00167-012-1971-0. Epub 2012 Apr 13.

Reference Type RESULT
PMID: 22527409 (View on PubMed)

Song JH, Shim HY, Lee TJ, Jung JK, Cha YD, Lee DI, Kim GW, Han JU. Comparison of dexmedetomidine and epinephrine as an adjuvant to 1% mepivacaine in brachial plexus block. Korean J Anesthesiol. 2014 Apr;66(4):283-9. doi: 10.4097/kjae.2014.66.4.283. Epub 2014 Apr 28.

Reference Type RESULT
PMID: 24851163 (View on PubMed)

Other Identifiers

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Mengücek gazi

Identifier Type: -

Identifier Source: org_study_id

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