The Born in Guangzhou Cohort Study (BIGCS)

NCT ID: NCT02526901

Last Updated: 2024-02-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-02-01

Study Completion Date

2030-12-31

Brief Summary

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The Born in Guangzhou Cohort Study (BIGCS) was established to investigate the short- and long-term effects of exposure in early life on health consequences in Guangzhou, China. Data are collected regarding environmental, occupational and lifestyle exposures as well as health outcomes in later life. Biological samples including blood and tissue samples are also collected from the participants.

Detailed Description

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Over the past three decades, China is undergoing rapidly economic development. At the same time, the Western diet and urban lifestyle has been more common than before, which may lead to an increase of incidence of non-communicable chronic diseases, such as diabetes and malignancies. Notably, the current generation of Chinese adults, particularly those in their middle age or older, were born in an era where hardship and rationing was the norm and witnessed a social and epidemiological transition that might have a profound effect on their present health. In contrast, the younger generation is raised in relative material abundance, under the influence of traditional Chinese values such as a strong family orientation and an emphasis on academic success. A birth cohort with would provide an opportunity to examine the short- and long-term effects of exposure in early life on health consequences in this younger generation, in the context of rapid development in China.

Conditions

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Intrauterine Hyperglycemia Pregnancy Outcomes Neurodevelopment Immune Development Childhood Obesity Host and Microbiome

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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No treatment

No intervention

Intervention Type OTHER

Interventions

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No intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Pregnant women with \<20 weeks of gestation
* Pregnant women intended to eventually deliver in Guangzhou Women and Children's Medical Center
* Permanent residents or families intended to remain in Guangzhou with their child for ≥3 years
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Birmingham

OTHER

Sponsor Role collaborator

Guangzhou Women and Children's Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Xiu Qiu

Director of the Born in Guangzhou Cohort Study

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xiu Qiu, PhD

Role: PRINCIPAL_INVESTIGATOR

Guangzhou Women and Children's Medical Center, China

Locations

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Guangzhou Women and Children's Medical Center

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Xiu Qiu, PhD

Role: CONTACT

0086 20 38367160

Jianrong He, MS

Role: CONTACT

0086 20 38367159

Facility Contacts

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Xiu Qiu, PhD

Role: primary

0086 20 38367160

Jianrong He, MS

Role: backup

0086 20 38367160

References

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He JR, Yuan MY, Chen NN, Lu JH, Hu CY, Mai WB, Zhang RF, Pan YH, Qiu L, Wu YF, Xiao WQ, Liu Y, Xia HM, Qiu X. Maternal dietary patterns and gestational diabetes mellitus: a large prospective cohort study in China. Br J Nutr. 2015 Apr 28;113(8):1292-300. doi: 10.1017/S0007114515000707. Epub 2015 Mar 30.

Reference Type BACKGROUND
PMID: 25821944 (View on PubMed)

Related Links

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Other Identifiers

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201041-E00741

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2012J5100038

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

201508030037

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

2011Y2-00025

Identifier Type: -

Identifier Source: org_study_id

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