Resveratrol and Exercise to Treat Functional Limitations in Late Life
NCT ID: NCT02523274
Last Updated: 2022-01-13
Study Results
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
PHASE2
60 participants
INTERVENTIONAL
2016-06-30
2019-07-17
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Exercise for Elderly Peripheral Revascularized Patients
NCT00667290
Acute Effect of Exercise on Vascular Function
NCT02408614
Reducing Blood Pressure in Mid-life Adult Binge Drinkers
NCT05522075
Blood Flow Restriction With Aerobic Exercise in Frail Older Adults
NCT06155227
Resistance Training to Improve Physical Function in the Elderly
NCT01385475
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Placebo + exercise
Placebo capsules will be taken orally daily in combination with exercise
Placebo
Vegetable-based cellulose
Exercise
Multi-modal exercise regimen, 3 days/week
Resveratrol 500 mg/day + exercise
500 mg/day resveratrol taken orally in combination with exercise
Resveratrol
Dietary compound commonly found in grapes and red wine. Will be given in 250 mg/day and 1000 mg/day dosages
Exercise
Multi-modal exercise regimen, 3 days/week
Resveratrol 1000 mg/day + exercise
1000 mg/day resveratrol taken orally in combination with exercise
Resveratrol
Dietary compound commonly found in grapes and red wine. Will be given in 250 mg/day and 1000 mg/day dosages
Exercise
Multi-modal exercise regimen, 3 days/week
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Resveratrol
Dietary compound commonly found in grapes and red wine. Will be given in 250 mg/day and 1000 mg/day dosages
Placebo
Vegetable-based cellulose
Exercise
Multi-modal exercise regimen, 3 days/week
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Willingness to be randomized into either treatment group
* Age 65 years and older
* Physical limitations evidenced by \>290 seconds needed to complete long-distance corridor walk test
* Sedentary lifestyle, defined as \<150 min/wk of moderate physical activity as assessed by CHAMPS questionnaire
Exclusion Criteria
* Regular consumption of a resveratrol supplement
* Current involvement in supervised rehabilitation program
* Absolute contraindication(s) to exercise training according to American College of Sports Medicine guidelines
* Pain classification \> Grade 3 on Graded Chronic Pain Scale
* Peripheral vascular disease; peripheral neuropathy; retinopathy
* Severe cardiac disease, including:
NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
* Myocardial infarction or stroke within past year
* Significant cognitive impairment, including:
known dementia diagnosis or a Mini-Mental State Examination exam score \<24
* Progressive, degenerative neurologic disease (e.g., Parkinson's Disease, multiple sclerosis, ALS)
* Severe rheumatologic or orthopedic diseases (e.g., awaiting joint replacement, active inflammatory disease)
* Severe pulmonary disease, requiring either steroid pills or injections or the use of supplemental oxygen
* Hip fracture, hip or knee replacement, or spinal surgery within past 4 mos.
* Other significant co-morbid conditions that would impair ability to participate in the exercise-based intervention
* Simultaneous participation in another intervention trial
65 Years
ALL
No
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
National Institute on Aging (NIA)
NIH
University of Alabama at Birmingham
OTHER
University of Florida
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Thomas Buford, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Alabama at Birmingham
Stephen Anton
Role: PRINCIPAL_INVESTIGATOR
University of Florida
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
UAB Center for Exercise Medicine
Birmingham, Alabama, United States
Countries
Review the countries where the study has at least one active or historical site.
Provided Documents
Download supplemental materials such as informed consent forms, study protocols, or participant manuals.
Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
IRB201500598 -N
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.