Medtronic RevElution Trial

NCT ID: NCT02480348

Last Updated: 2020-07-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

109 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-03

Study Completion Date

2019-10-21

Brief Summary

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The purpose of this trial is to evaluate the clinical safety and efficacy of the Polymer-Free Drug-Eluting coronary stent system for the treatment of de novo lesions in native coronary arteries with a reference vessel diameter (RVD) that allows use of stents between 2.25 and 3.50 mm in diameter.

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Polymer-free DES (Drug Eluting Stent)

Group Type EXPERIMENTAL

Polymer-free DES (Drug Eluting Stent)

Intervention Type DEVICE

Interventions

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Polymer-free DES (Drug Eluting Stent)

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Must be an acceptable candidate for percutaneous coronary intervention, stenting, \& emergent coronary artery bypass graft (CABG) surgery
* Must have evidence of ischemic heart disease
* Must require treatment of either a) a single target lesion amenable to treatment with a 2.25 mm - 3.50 mm stent OR b) two target lesions located in separate target vessels, with at least one of the target lesions amenable to treatment with a 2.25 mm - 3.50 mm mm study stent
* Target lesion(s) must be de novo lesion(s) in native coronary artery(ies)

Exclusion Criteria

* Known hypersensitivity or contraindication to aspirin, heparin and bivalirudin, thienopyridines, cobalt, nickel, platinum, iridium, chromium, molybdenum, polymer coatings (e.g. BioLinx) or a sensitivity to contrast media, which cannot be adequately pre-medicated
* History of an allergic reaction or significant sensitivity to drugs such as zotarolimus, rapamycin, tacrolimus, everolimus, or any other analogue or derivative
* History of a stroke or transient ischemic attack (TIA) within the prior 6 months
* Active peptic ulcer or upper gastrointestinal (GI) bleeding within the prior 6 months
* History of bleeding diathesis or coagulopathy or will refuse blood transfusions
* Concurrent medical condition with a life expectancy of less than 5 years
* Currently participating in an investigational drug or another device trial that has not completed the primary endpoint
* Documented left ventricular ejection fraction (LVEF) \< 30% at the most recent evaluation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic Vascular

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Eastern Heart Clinic - Prince of Wales Hospital

Sydney, New South Wales, Australia

Site Status

The Prince Charles Hospital

Chermside, Queensland, Australia

Site Status

St. Andrew's Hospital

Adelaide, South Australia, Australia

Site Status

Royal Adelaide Hospital

Adelaide, , Australia

Site Status

Wesley Hospital / HeartCare Partners

Auchenflower, , Australia

Site Status

Flinders Medical Center

Bedford Park, , Australia

Site Status

St. Vincent's Hospital

Darlinghurst, , Australia

Site Status

Royal Brisbane & Women's Hospital

Herston, , Australia

Site Status

Monash Medical Center

Melbourne, , Australia

Site Status

Northern Hospital

Melbourne, , Australia

Site Status

Fiona Stanley Hospital

Murdoch, , Australia

Site Status

John Hunter Hospital

New Lambton, , Australia

Site Status

Royal North Shore Hospital

St Leonards, , Australia

Site Status

Institute Dante Pazzanese of Cardiology

São Paulo, , Brazil

Site Status

National Heart Center Singapore

Singapore, , Singapore

Site Status

Countries

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Australia Brazil Singapore

References

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Worthley SG, Abizaid A, Kirtane AJ, Simon DI, Windecker S, Brar S, Meredith IT, Shetty S, Sinhal A, Almonacid AP, Chamie D, Maehara A, Stone GW; RevElution Investigators. First-in-Human Evaluation of a Novel Polymer-Free Drug-Filled Stent: Angiographic, IVUS, OCT, and Clinical Outcomes From the RevElution Study. JACC Cardiovasc Interv. 2017 Jan 23;10(2):147-156. doi: 10.1016/j.jcin.2016.10.020.

Reference Type DERIVED
PMID: 28104208 (View on PubMed)

Other Identifiers

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Version 5.0, 29 JUL 2019

Identifier Type: -

Identifier Source: org_study_id

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