Bare Metal Stent Versus Drug Coated Balloon With Provisional Stenting in Non-ST-Elevation Myocardial Infarction

NCT ID: NCT01489449

Last Updated: 2023-05-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

210 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-12-31

Study Completion Date

2022-06-23

Brief Summary

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The aim of the present trial is to assess the efficacy of the standalone use of SeQuent(R) Please coated balloon compared to a bare metal stent (BMS) in patients with NSTEMI.

Detailed Description

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The aim of the present trial is to assess the efficacy of the standalone use of SeQuent(R) Please coated balloon compared to a bare metal stent (BMS) in patients with NSTEMI. Primary efficacy endpoint will be MACE (cardiac mortality, reinfarction, and target lesion revascularization) after 9 months.

Conditions

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Coronary Heart Disease NSTEMI

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Stent

Stent Implantation (DES or BMS), no further treatment

Group Type PLACEBO_COMPARATOR

Stent

Intervention Type DEVICE

bare metal stent implantation, any bare metal stent is allowed from different companies

DCB

"DEBonly" strategy: treatment with drug coated balloon, additional spot-stenting in case of severe dissection

Group Type ACTIVE_COMPARATOR

SeQuent(R) Please coated balloon

Intervention Type COMBINATION_PRODUCT

Angioplasty with Drug coated balloon (DCB)

Interventions

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Stent

bare metal stent implantation, any bare metal stent is allowed from different companies

Intervention Type DEVICE

SeQuent(R) Please coated balloon

Angioplasty with Drug coated balloon (DCB)

Intervention Type COMBINATION_PRODUCT

Other Intervention Names

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SeQuent(R) Please

Eligibility Criteria

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Inclusion Criteria

* NSTEMI with
* Ischemic symptoms (angina pectoris) \> 30 minutes
* Last symptoms within 72 hours before randomization
* Positive cardiac troponin T, I, or hs-Troponin above 99th percentile
* age \> 18 years
* Identifiable culprit lesion without angiographic evidence of large thrombus with intended early PCI (treatment of up to two lesions allowed)

Exclusion Criteria

* Cardiogenic shock
* ST-elevation myocardial infarction
* No identifiable culprit lesion, Indication for acute bypass surgery
* Comorbidity with limited life expectancy \< 9-12 months
* Contraindication for treatment with heparin, ASA and thienopyridines
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Saarland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bruno Scheller, MD

Role: PRINCIPAL_INVESTIGATOR

Klinik fuer Innere Medizin III, Universitaetsklinikum des Saarlandes

Locations

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Klinik fuer Innere Medizin III, Universitaetsklinikum des Saarlandes

Homburg/Saar, Saarland, Germany

Site Status

Countries

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Germany

Other Identifiers

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PEPCAD NSTEMI

Identifier Type: -

Identifier Source: org_study_id

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