Early Cycloergometric Physiotherapy in Critically Ill Patients With Invasive Mechanical Ventilation

NCT ID: NCT02478411

Last Updated: 2019-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

68 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-06-30

Study Completion Date

2021-06-30

Brief Summary

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Study designed to evaluate the functional and motor effects in critically ill subjects at ICU and hospital discharge with the incorporation of a mobilization program of cycloergometric physiotherapy sessions compared with conventional physiotherapy.

Detailed Description

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Cycloergometric treatment is described to improve the functional and motor status of critically ill subjects. However, there are few studies comparing cycloergometric physiotherapy and conventional physiotherapy in intensive care subjects under mechanical ventilation. The most relevant of these studies conducted by Burtin et al showed beneficial effects of cycloergometric treatment. However, the duration of the physiotherapy sessions in this study differed between groups as cycloergometric group received a double daily dose of treatment. It is known that the intensity of physiotherapy also affects the functional and motor status.

For this reason, the investigators designed a randomized controlled study with early cycloergometric or conventional treatment, with the same intensity between groups to analyze objective functional and motor endpoints.

Conditions

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Weakness

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Cycle ergometer physiotherapy

15 minutes of cycle ergometer physiotherapy plus 15 minutes of conventional physiotherapy, once daily, five days a week, as long as patients remain in the intensive care unit

Group Type EXPERIMENTAL

Cycle ergometer physiotherapy

Intervention Type PROCEDURE

15 minutes of cyclo ergometer physiotherapy with MOTOmed ® Letto 2 device with passive, motor-assisted and active-resisted exercise of the lower and upper extremity, and 15 minutes of conventional physiotherapy

Conventional physiotherapy

30 minutes of conventional physiotherapy, once daily, five days a week, as long as patients remain in the intensive care unit

Group Type ACTIVE_COMPARATOR

Conventional physiotherapy

Intervention Type PROCEDURE

30 minutes of conventional physiotherapy

Interventions

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Cycle ergometer physiotherapy

15 minutes of cyclo ergometer physiotherapy with MOTOmed ® Letto 2 device with passive, motor-assisted and active-resisted exercise of the lower and upper extremity, and 15 minutes of conventional physiotherapy

Intervention Type PROCEDURE

Conventional physiotherapy

30 minutes of conventional physiotherapy

Intervention Type PROCEDURE

Other Intervention Names

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MOTOmed ® Letto 2

Eligibility Criteria

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Inclusion Criteria

* Criteria of functional independence before hospital admission (Barthel scale \> 70 points).
* Invasive mechanical ventilation \< 72 hours.
* Signed informed consent.

Exclusion Criteria

* Neuromuscular disease (peripheric or central neurologic disorder).
* Presumed fatal evolution in 48 hours.
* Conditions that impede pedaling movement (leg, pelvis or lumbar spinal surgery or traumatism).
* Admission due to cardiac arrest.
* Pregnancy.
* Thrombopenia less than 50.000.
* Severe agitation.
* Hemodynamic instability with noradrenaline requirements greater than 1 mcg/kg/min.
* Fraction of inspired Oxygen (FiO2) requirements greater that 0.55 and respiratory rate greater than 30 bpm.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospital Son Llatzer

OTHER

Sponsor Role lead

Responsible Party

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Gemma Rialp

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gemma Rialp, M.D.

Role: PRINCIPAL_INVESTIGATOR

IDISPA

Locations

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Hospital Son llàtzer

Palma de Mallorca, Balearic Islands, Spain

Site Status RECRUITING

Countries

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Spain

Central Contacts

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Gemma Rialp, M.D.

Role: CONTACT

00 34 871202133

Catalina Morey, Phyt

Role: CONTACT

Facility Contacts

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Gemma Rialp, M.D.

Role: primary

00 34 871202133

References

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De Jonghe B, Sharshar T, Lefaucheur JP, Authier FJ, Durand-Zaleski I, Boussarsar M, Cerf C, Renaud E, Mesrati F, Carlet J, Raphael JC, Outin H, Bastuji-Garin S; Groupe de Reflexion et d'Etude des Neuromyopathies en Reanimation. Paresis acquired in the intensive care unit: a prospective multicenter study. JAMA. 2002 Dec 11;288(22):2859-67. doi: 10.1001/jama.288.22.2859.

Reference Type RESULT
PMID: 12472328 (View on PubMed)

TEAM Study Investigators; Hodgson C, Bellomo R, Berney S, Bailey M, Buhr H, Denehy L, Harrold M, Higgins A, Presneill J, Saxena M, Skinner E, Young P, Webb S. Early mobilization and recovery in mechanically ventilated patients in the ICU: a bi-national, multi-centre, prospective cohort study. Crit Care. 2015 Feb 26;19(1):81. doi: 10.1186/s13054-015-0765-4.

Reference Type RESULT
PMID: 25715872 (View on PubMed)

Schweickert WD, Kress JP. Implementing early mobilization interventions in mechanically ventilated patients in the ICU. Chest. 2011 Dec;140(6):1612-1617. doi: 10.1378/chest.10-2829.

Reference Type RESULT
PMID: 22147819 (View on PubMed)

Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, Spears L, Miller M, Franczyk M, Deprizio D, Schmidt GA, Bowman A, Barr R, McCallister KE, Hall JB, Kress JP. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009 May 30;373(9678):1874-82. doi: 10.1016/S0140-6736(09)60658-9. Epub 2009 May 14.

Reference Type RESULT
PMID: 19446324 (View on PubMed)

Needham DM, Truong AD, Fan E. Technology to enhance physical rehabilitation of critically ill patients. Crit Care Med. 2009 Oct;37(10 Suppl):S436-41. doi: 10.1097/CCM.0b013e3181b6fa29.

Reference Type RESULT
PMID: 20046132 (View on PubMed)

Burtin C, Clerckx B, Robbeets C, Ferdinande P, Langer D, Troosters T, Hermans G, Decramer M, Gosselink R. Early exercise in critically ill patients enhances short-term functional recovery. Crit Care Med. 2009 Sep;37(9):2499-505. doi: 10.1097/CCM.0b013e3181a38937.

Reference Type RESULT
PMID: 19623052 (View on PubMed)

Bourdin G, Barbier J, Burle JF, Durante G, Passant S, Vincent B, Badet M, Bayle F, Richard JC, Guerin C. The feasibility of early physical activity in intensive care unit patients: a prospective observational one-center study. Respir Care. 2010 Apr;55(4):400-7.

Reference Type RESULT
PMID: 20406506 (View on PubMed)

Other Identifiers

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CYCLE-ICU-001

Identifier Type: -

Identifier Source: org_study_id

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