A Pilot Evaluation of Mindfulness-based Cognitive Therapy for People With Huntington's Disease
NCT ID: NCT02464293
Last Updated: 2020-01-07
Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
NA
Total Enrollment
16 participants
Study Classification
INTERVENTIONAL
Study Start Date
2015-06-30
Study Completion Date
2018-01-31
Brief Summary
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This is a pilot study to see whether mindfulness-based cognitive therapy, which is a type of psychological therapy, is able to improve the psychological wellbeing of people who have the gene for Huntington's disease.
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Detailed Description
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Huntingdon's disease (HD) is a genetic neurodegenerative condition which causes problems with movement, coordination and cognitive functioning, and emotional difficulties are also commonly experienced. It is believed to affect around five to ten in 100,000 people of European descent, with recent UK estimates as high as 11.2-13.5. Each child of an affected person has a 50% chance of inheriting the condition. As age of diagnosis is typically around 35-55, with time from diagnosis to death around 20 years, those who are diagnosed have often seen their parents affected by the condition.
Many people at various stages of HD (including those who carry the gene but are pre-symptomatic) experience low mood, anxiety and other psychological difficulties. Indeed, alongside functional capacity, mood may be one of the main factors which contributes to health related quality of life, more so than discrete motor problems, or cognitive impairment. In addition, reports from patients suggest emotional and social concerns are important for individuals with the condition at the pre-symptomatic stage, and these concerns remain throughout the disease course. Medication may be effective to alleviate psychological difficulties for some people, but its efficacy has not been conclusively proven and it is not suitable for all. Psychological interventions may provide an alternative or additional way of alleviating distress.
Although it is commonly presumed that biological factors are the main determinants of psychological distress in people with HD, several studies have indicated that, while these may indeed be important, psychological factors are also significant. For example beliefs about the disease and coping mechanisms are associated with poorer mental health and higher levels of depression. Such psychological beliefs and coping patterns can be adaptively changed using psychological interventions, for example cognitive-based psychological therapies.
Little progress has been reported on the development of psychological interventions in HD despite the fact that people with HD have expressed an interest in psychological approaches and these are currently being successfully developed for people with other neurological conditions (e.g., in people with Parkinson's disease). It is therefore proposed to pilot mindfulness-based cognitive therapy (MBCT) which, although originally developed to help people with remitted depression from relapse, has been increasingly used to help people with current difficulties. It has also been piloted with people with Parkinson's disease who found it an acceptable intervention and reported improvements in self-management and psychological wellbeing. In general, MBCT has also recorded other gains including improved sleep quality and social functioning. It has also received sufficient evidence for it to be a recommended approach in the UK NICE guidelines for people with a history of depression. MBCT can also reduce anxiety and provides group support. There are also indications that mindfulness training can improve neurocognitive functioning, even in people with neurodegenerative disease. Finally, a psychological therapy subgroup within the European Huntington's Disease Network has recently been formed, thus indicating the rise of interest in psychological approaches and the timely nature of this work.
Hence this study will provide the first indication of whether MBCT, a therapeutic approach with an established evidence base, would be acceptable and useful for people with HD. In order to meet this aim, MBCT will be delivered to two groups, one to individuals who carry the gene but are pre-symptomatic and one to individuals who have begun to experience symptoms but are at an early stage of the disease course.
Approaches to outcome evaluation should be incremental, with lower cost studies, e.g., qualitative investigations and case studies, being conducted before investment in randomised controlled trials is considered. Thus this study will follow this guidance by collecting both qualitative and quantitative data. The qualitative data will be analysed using interpretative phenomenological analysis, a methodology previously used in other qualitative studies on MBCT. Semi-structured interviews will provide data on the acceptability of the intervention and detailed accounts of participants' experience after the intervention has been provided. This will inform whether the MBCT intervention needs to be changed or adapted in further trials. The quantitative data will be used to provide basic pre and post intervention comparisons on a number of outcome variables relevant to MBCT, with the hypothesis that performance on these measures will improve post training. These data will also be used to estimate effect sizes for further trials so that these are suitably powered.
Given the considerable physical, cognitive and emotional consequences of the disease, HD not only affects the person with HD, but also those with whom they live, even in the pre-clinical phase. Family members often become caregivers and can have a reduced quality of life as a result, including experiencing low mood themselves. In fact, caregiver burden and caregiver depression is associated with depression of the person with HD and, alongside motor disturbances, depression of the person with HD is one of the main predictors of caregiver burden. Partners of people with HD can also experience reduced satisfaction with their relationship, sometimes more so than the person with HD themselves.
Thus this study will also investigate the views of a family member (e.g. partner, parent, child) of the person participating in the intervention. As the intervention is aimed at alleviating psychological distress in the person with HD, it is hypothesised that this in turn will also have an effect on the family member's wellbeing. Also, higher levels of mindfulness are associated with higher levels of satisfaction in partner relationships, perhaps due to more adaptive conflict resolution and better emotional recognition and management. Participants in MBCT have reported increased empathy and perspective taking, being more able to respond mindfully in relationships. Thus increased mindfulness of the person with HD may benefit family and social relationships.
In addition, caregivers' views about the symptoms or quality of life of the person with HD may not always match the person with HD themselves. Furthermore, certain symptom changes which are beneficial to the person with HD may not be so to the caregiver, and thus the caregiver can offer an alternative perspective of the wellbeing (including behavioural and psychological changes) of the person with HD.
Both qualitative and quantitative data will be collected from a family member or close friend of the person with HD, where such a person is available and willing to take part. Semi-structured interviews with the family member will explore their perceptions on the acceptability of the intervention and experiences of the person with HD, as well as the impact on the family member personally and the wider family system. Data collected pre and post the intervention will assess any changes in their psychological wellbeing, caregiver burden and family relationships, with the hypothesis that wellbeing and relationships will improve post training and caregiver burden will decrease.
Many people at various stages of HD (including those who carry the gene but are pre-symptomatic) experience low mood, anxiety and other psychological difficulties. Indeed, alongside functional capacity, mood may be one of the main factors which contributes to health related quality of life, more so than discrete motor problems, or cognitive impairment. In addition, reports from patients suggest emotional and social concerns are important for individuals with the condition at the pre-symptomatic stage, and these concerns remain throughout the disease course. Medication may be effective to alleviate psychological difficulties for some people, but its efficacy has not been conclusively proven and it is not suitable for all. Psychological interventions may provide an alternative or additional way of alleviating distress.
Although it is commonly presumed that biological factors are the main determinants of psychological distress in people with HD, several studies have indicated that, while these may indeed be important, psychological factors are also significant. For example beliefs about the disease and coping mechanisms are associated with poorer mental health and higher levels of depression. Such psychological beliefs and coping patterns can be adaptively changed using psychological interventions, for example cognitive-based psychological therapies.
Little progress has been reported on the development of psychological interventions in HD despite the fact that people with HD have expressed an interest in psychological approaches and these are currently being successfully developed for people with other neurological conditions (e.g., in people with Parkinson's disease). It is therefore proposed to pilot mindfulness-based cognitive therapy (MBCT) which, although originally developed to help people with remitted depression from relapse, has been increasingly used to help people with current difficulties. It has also been piloted with people with Parkinson's disease who found it an acceptable intervention and reported improvements in self-management and psychological wellbeing. In general, MBCT has also recorded other gains including improved sleep quality and social functioning. It has also received sufficient evidence for it to be a recommended approach in the UK NICE guidelines for people with a history of depression. MBCT can also reduce anxiety and provides group support. There are also indications that mindfulness training can improve neurocognitive functioning, even in people with neurodegenerative disease. Finally, a psychological therapy subgroup within the European Huntington's Disease Network has recently been formed, thus indicating the rise of interest in psychological approaches and the timely nature of this work.
Hence this study will provide the first indication of whether MBCT, a therapeutic approach with an established evidence base, would be acceptable and useful for people with HD. In order to meet this aim, MBCT will be delivered to two groups, one to individuals who carry the gene but are pre-symptomatic and one to individuals who have begun to experience symptoms but are at an early stage of the disease course.
Approaches to outcome evaluation should be incremental, with lower cost studies, e.g., qualitative investigations and case studies, being conducted before investment in randomised controlled trials is considered. Thus this study will follow this guidance by collecting both qualitative and quantitative data. The qualitative data will be analysed using interpretative phenomenological analysis, a methodology previously used in other qualitative studies on MBCT. Semi-structured interviews will provide data on the acceptability of the intervention and detailed accounts of participants' experience after the intervention has been provided. This will inform whether the MBCT intervention needs to be changed or adapted in further trials. The quantitative data will be used to provide basic pre and post intervention comparisons on a number of outcome variables relevant to MBCT, with the hypothesis that performance on these measures will improve post training. These data will also be used to estimate effect sizes for further trials so that these are suitably powered.
Given the considerable physical, cognitive and emotional consequences of the disease, HD not only affects the person with HD, but also those with whom they live, even in the pre-clinical phase. Family members often become caregivers and can have a reduced quality of life as a result, including experiencing low mood themselves. In fact, caregiver burden and caregiver depression is associated with depression of the person with HD and, alongside motor disturbances, depression of the person with HD is one of the main predictors of caregiver burden. Partners of people with HD can also experience reduced satisfaction with their relationship, sometimes more so than the person with HD themselves.
Thus this study will also investigate the views of a family member (e.g. partner, parent, child) of the person participating in the intervention. As the intervention is aimed at alleviating psychological distress in the person with HD, it is hypothesised that this in turn will also have an effect on the family member's wellbeing. Also, higher levels of mindfulness are associated with higher levels of satisfaction in partner relationships, perhaps due to more adaptive conflict resolution and better emotional recognition and management. Participants in MBCT have reported increased empathy and perspective taking, being more able to respond mindfully in relationships. Thus increased mindfulness of the person with HD may benefit family and social relationships.
In addition, caregivers' views about the symptoms or quality of life of the person with HD may not always match the person with HD themselves. Furthermore, certain symptom changes which are beneficial to the person with HD may not be so to the caregiver, and thus the caregiver can offer an alternative perspective of the wellbeing (including behavioural and psychological changes) of the person with HD.
Both qualitative and quantitative data will be collected from a family member or close friend of the person with HD, where such a person is available and willing to take part. Semi-structured interviews with the family member will explore their perceptions on the acceptability of the intervention and experiences of the person with HD, as well as the impact on the family member personally and the wider family system. Data collected pre and post the intervention will assess any changes in their psychological wellbeing, caregiver burden and family relationships, with the hypothesis that wellbeing and relationships will improve post training and caregiver burden will decrease.
Conditions
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Huntington Disease
Study Design
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Allocation Method
NA
Intervention Model
SINGLE_GROUP
Primary Study Purpose
TREATMENT
Blinding Strategy
NONE
Study Groups
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mindfulness-based cognitive therapy
Group Type
EXPERIMENTAL
Mindfulness-based cognitive therapy
Intervention Type
OTHER
An 8 week course of mindfulness-based cognitive therapy
Interventions
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Mindfulness-based cognitive therapy
An 8 week course of mindfulness-based cognitive therapy
Intervention Type
OTHER
Eligibility Criteria
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Inclusion Criteria
For those with HD:
Patient at Manchester Centre for Genomic Medicine (UK)
* All participants will have had genetic testing and shown to have the requisite CAG expansion on the huntingtin gene.
* Participants must be pre-symptomatic or at stage 1 (still able to function at home and at work and handle financial affairs)
* Clinical sign of depression (score on HADS of 7 or above)
* No significant medication changes in 6 weeks prior to starting the course
For those who are relatives or friends of those with HD:
* Must be a relative or friend of someone participating in the MBCT course
Patient at Manchester Centre for Genomic Medicine (UK)
* All participants will have had genetic testing and shown to have the requisite CAG expansion on the huntingtin gene.
* Participants must be pre-symptomatic or at stage 1 (still able to function at home and at work and handle financial affairs)
* Clinical sign of depression (score on HADS of 7 or above)
* No significant medication changes in 6 weeks prior to starting the course
For those who are relatives or friends of those with HD:
* Must be a relative or friend of someone participating in the MBCT course
Exclusion Criteria
* Active suicidal intent
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Manchester University NHS Foundation Trust
OTHER_GOV
Sponsor Role
collaborator
Lancaster University
OTHER
Sponsor Role
lead
Responsible Party
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Dr Jane Simpson
Research Director, Doctorate in Clinical Psychology
Responsibility Role
PRINCIPAL_INVESTIGATOR
Principal Investigators
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Jane Simpson, PhD
Role: PRINCIPAL_INVESTIGATOR
Lancaster University
Locations
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Central Manchester University Hospitals NHS Foundation Trust
Manchester, , United Kingdom
Site Status
Countries
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United Kingdom
References
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Arran N, Craufurd D, Simpson J. Illness perceptions, coping styles and psychological distress in adults with Huntington's disease. Psychol Health Med. 2014;19(2):169-79. doi: 10.1080/13548506.2013.802355. Epub 2013 Jun 14.
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Kristjanson LJ, Aoun SM, Oldham L. Palliative care and support for people with neurodegenerative conditions and their carers. Int J Palliat Nurs. 2006 Aug;12(8):368-77. doi: 10.12968/ijpn.2006.12.8.368.
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Aubeeluck A, Buchanan H. The Huntington's disease quality of life battery for carers: reliability and validity. Clin Genet. 2007 May;71(5):434-45. doi: 10.1111/j.1399-0004.2007.00784.x.
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Aubeeluck AV, Buchanan H, Stupple EJ. 'All the burden on all the carers': exploring quality of life with family caregivers of Huntington's disease patients. Qual Life Res. 2012 Oct;21(8):1425-35. doi: 10.1007/s11136-011-0062-x. Epub 2011 Nov 13.
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Banaszkiewicz K, Sitek EJ, Rudzinska M, Soltan W, Slawek J, Szczudlik A. Huntington's disease from the patient, caregiver and physician's perspectives: three sides of the same coin? J Neural Transm (Vienna). 2012 Nov;119(11):1361-5. doi: 10.1007/s00702-012-0787-x. Epub 2012 Mar 8.
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Barnhofer T, Crane C, Hargus E, Amarasinghe M, Winder R, Williams JM. Mindfulness-based cognitive therapy as a treatment for chronic depression: A preliminary study. Behav Res Ther. 2009 May;47(5):366-73. doi: 10.1016/j.brat.2009.01.019. Epub 2009 Feb 5.
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Bihari, J, Mullan, E. Relating Mindfully: A Qualitative Exploration of Changes in Relationships Through Mindfulness-Based Cognitive Therapy. Mindfulness 5(1): 46-59, 2014.
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Cairns V, Murray C. How do the features of mindfulness-based cognitive therapy contribute to positive therapeutic change? A meta-synthesis of qualitative studies. Behav Cogn Psychother. 2015 May;43(3):342-59. doi: 10.1017/S1352465813000945. Epub 2013 Nov 11.
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BACKGROUND
Craufurd, D, Snowden, JS. Neuropsychiatry and Neuropsychology. In G Bates, SJ Tabrizi, L Jones (Eds.), Huntington's disease (4th ed., pp. 36-65). Oxford: Oxford University Press. (2014)
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BACKGROUND
Craufurd D, Thompson JC, Snowden JS. Behavioral changes in Huntington Disease. Neuropsychiatry Neuropsychol Behav Neurol. 2001 Oct-Dec;14(4):219-26.
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Dobkin RD, Menza M, Allen LA, Gara MA, Mark MH, Tiu J, Bienfait KL, Friedman J. Cognitive-behavioral therapy for depression in Parkinson's disease: a randomized, controlled trial. Am J Psychiatry. 2011 Oct;168(10):1066-74. doi: 10.1176/appi.ajp.2011.10111669. Epub 2011 Jun 15.
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Eisendrath SJ, Delucchi K, Bitner R, Fenimore P, Smit M, McLane M. Mindfulness-based cognitive therapy for treatment-resistant depression: a pilot study. Psychother Psychosom. 2008;77(5):319-20. doi: 10.1159/000142525. Epub 2008 Jul 4. No abstract available.
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Evans SJ, Douglas I, Rawlins MD, Wexler NS, Tabrizi SJ, Smeeth L. Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records. J Neurol Neurosurg Psychiatry. 2013 Oct;84(10):1156-60. doi: 10.1136/jnnp-2012-304636. Epub 2013 Mar 12.
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BACKGROUND
Fitzpatrick L, Simpson J, Smith A. A qualitative analysis of mindfulness-based cognitive therapy (MBCT) in Parkinson's disease. Psychol Psychother. 2010 Jun;83(Pt 2):179-92. doi: 10.1348/147608309X471514. Epub 2009 Oct 19.
Reference Type
BACKGROUND
Griffiths K, Camic PM, Hutton JM. Participant experiences of a mindfulness-based cognitive therapy group for cardiac rehabilitation. J Health Psychol. 2009 Jul;14(5):675-81. doi: 10.1177/1359105309104911.
Reference Type
BACKGROUND
Helder DI, Kaptein AA, Van Kempen GM, Weinman J, Van Houwelingen HC, Roos RA. Living with Huntington's disease: Illness perceptions, coping mechanisms, and patients' well-being. Br J Health Psychol. 2002 Nov;7(Part 4):449-462. doi: 10.1348/135910702320645417.
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BACKGROUND
Ho AK, Gilbert AS, Mason SL, Goodman AO, Barker RA. Health-related quality of life in Huntington's disease: Which factors matter most? Mov Disord. 2009 Mar 15;24(4):574-8. doi: 10.1002/mds.22412.
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BACKGROUND
Ho AK, Hocaoglu MB; European Huntington's Disease Network Quality of Life Working Group. Impact of Huntington's across the entire disease spectrum: the phases and stages of disease from the patient perspective. Clin Genet. 2011 Sep;80(3):235-9. doi: 10.1111/j.1399-0004.2011.01748.x. Epub 2011 Aug 4.
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Jha AP, Stanley EA, Kiyonaga A, Wong L, Gelfand L. Examining the protective effects of mindfulness training on working memory capacity and affective experience. Emotion. 2010 Feb;10(1):54-64. doi: 10.1037/a0018438.
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Julien CL, Thompson JC, Wild S, Yardumian P, Snowden JS, Turner G, Craufurd D. Psychiatric disorders in preclinical Huntington's disease. J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):939-43. doi: 10.1136/jnnp.2006.103309. Epub 2006 Dec 18.
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BACKGROUND
Kaptein, A.A, Helder, DI, Scharloo, M, Van Kempen, GMJ, Weinman, J, Van Houwelingen, HJC, Roos, RAC. Illness perceptions and coping explain well-being in patients with Huntington's disease. Psychology & Health, 21(4): 431-446. (2006)
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Kaptein AA, Scharloo M, Helder DI, Snoei L, van Kempen GM, Weinman J, van Houwelingen JC, Roos RA. Quality of life in couples living with Huntington's disease: the role of patients' and partners' illness perceptions. Qual Life Res. 2007 Jun;16(5):793-801. doi: 10.1007/s11136-007-9194-4. Epub 2007 Mar 21.
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BACKGROUND
Kay, C, Fisher, E, Hayden, MR. Epidemiology. In G. Bates, S. J. Tabrizi & L. Jones (Eds.), Huntington's disease (4th ed., pp. 131-164). Oxford: Oxford University Press. 2014.
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Lowit A, van Teijlingen ER. Avoidance as a strategy of (not) coping: qualitative interviews with carers of Huntington's Disease patients. BMC Fam Pract. 2005 Sep 14;6:38. doi: 10.1186/1471-2296-6-38.
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BACKGROUND
Ma SH, Teasdale JD. Mindfulness-based cognitive therapy for depression: replication and exploration of differential relapse prevention effects. J Consult Clin Psychol. 2004 Feb;72(1):31-40. doi: 10.1037/0022-006X.72.1.31.
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Marciniak R, Sheardova K, Cermakova P, Hudecek D, Sumec R, Hort J. Effect of meditation on cognitive functions in context of aging and neurodegenerative diseases. Front Behav Neurosci. 2014 Jan 27;8:17. doi: 10.3389/fnbeh.2014.00017. eCollection 2014.
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McCabe MP, Firth L, O'Connor E. A comparison of mood and quality of life among people with progressive neurological illnesses and their caregivers. J Clin Psychol Med Settings. 2009 Dec;16(4):355-62. doi: 10.1007/s10880-009-9168-5. Epub 2009 Jul 29.
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Mestre TA, Ferreira JJ. An evidence-based approach in the treatment of Huntington's disease. Parkinsonism Relat Disord. 2012 May;18(4):316-20. doi: 10.1016/j.parkreldis.2011.10.021. Epub 2011 Dec 16.
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Newberg AB, Serruya M, Wintering N, Moss AS, Reibel D, Monti DA. Meditation and neurodegenerative diseases. Ann N Y Acad Sci. 2014 Jan;1307:112-123. doi: 10.1111/nyas.12187. Epub 2013 Aug 7.
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Paulsen JS, Ready RE, Hamilton JM, Mega MS, Cummings JL. Neuropsychiatric aspects of Huntington's disease. J Neurol Neurosurg Psychiatry. 2001 Sep;71(3):310-4. doi: 10.1136/jnnp.71.3.310.
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Pickett T, Altmaier E, Paulsen, JS. Caregiver burden in Huntington's disease. Rehabilitation Psychology 52(3): 311-318. 2007.
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Ready RE, Mathews M, Leserman A, Paulsen JS. Patient and caregiver quality of life in Huntington's disease. Mov Disord. 2008 Apr 15;23(5):721-6. doi: 10.1002/mds.21920.
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Ree MJ, Craigie M A. Outcomes following mindfulness-based cognitive therapy in a heterogeneous sample of adult outpatients. Behavior Change 24(2): 70-86, 2007.
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Smith JA. Interpretative phenomenological analysis : theory, method and research. London: Sage. 2009.
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Spinney L. Uncovering the true prevalence of Huntington's disease. Lancet Neurol. 2010 Aug;9(8):760-1. doi: 10.1016/S1474-4422(10)70160-5. Epub 2010 Jun 30. No abstract available.
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Splevins K, Smith A, Simpson J. Do improvements in emotional distress correlate with becoming more mindful? A study of older adults. Aging Ment Health. 2009 May;13(3):328-35. doi: 10.1080/13607860802459807.
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Teasdale JD, Segal ZV, Williams JM, Ridgeway VA, Soulsby JM, Lau MA. Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy. J Consult Clin Psychol. 2000 Aug;68(4):615-23. doi: 10.1037//0022-006x.68.4.615.
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Teasdale JD, Williams JMG, Segal, ZV. The Mindful Way Workbook: An 8-week Program to Free Yourself from Depression and Emotional Distress. New York, New York: Guildford Press. 2014.
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Videnovic A. Treatment of huntington disease. Curr Treat Options Neurol. 2013 Aug;15(4):424-38. doi: 10.1007/s11940-013-0219-8.
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Wachs K, Cordova JV. Mindful relating: exploring mindfulness and emotion repertoires in intimate relationships. J Marital Fam Ther. 2007 Oct;33(4):464-81. doi: 10.1111/j.1752-0606.2007.00032.x.
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Williams JK, Hamilton R, Nehl C, McGonigal-Kenney M, Schutte DL, Sparbel K, Birrer E, Tripp-Reimer T, Friedrich R, Penziner E, Jarmon L, Paulsen J. "No one else sees the difference: "family members' perceptions of changes in persons with preclinical Huntington disease. Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144B(5):636-41. doi: 10.1002/ajmg.b.30479.
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Williams JK, Skirton H, Paulsen JS, Tripp-Reimer T, Jarmon L, McGonigal Kenney M, Birrer E, Hennig BL, Honeyford J. The emotional experiences of family carers in Huntington disease. J Adv Nurs. 2009 Apr;65(4):789-98. doi: 10.1111/j.1365-2648.2008.04946.x. Epub 2009 Feb 9.
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Winbush NY, Gross CR, Kreitzer MJ. The effects of mindfulness-based stress reduction on sleep disturbance: a systematic review. Explore (NY). 2007 Nov-Dec;3(6):585-91. doi: 10.1016/j.explore.2007.08.003.
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BACKGROUND
Eccles FJR, Craufurd D, Smith A, Davies R, Glenny K, Homberger M, Peeren S, Rogers D, Rose L, Skitt Z, Theed R, Simpson J. A feasibility investigation of mindfulness-based cognitive therapy for people with Huntington's disease. Pilot Feasibility Stud. 2020 Jun 24;6:90. doi: 10.1186/s40814-020-00631-z. eCollection 2020.
Reference Type
DERIVED
Related Links
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http://www.mrc.ac.uk/Utilities/Documentrecord/index.htm?d=MRC004871
Medical Research Council. (2008). Developing and evaluating complex interventions: new guidance.
Other Identifiers
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15/NW/0238
Identifier Type: OTHER
Identifier Source: secondary_id
EHDN Seed Fund Project 561
Identifier Type: -
Identifier Source: org_study_id
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NCT06621108
NOT_YET_RECRUITING
Feasibility Study on the Use of Mindfulness-based Intervention for Family Carers of People With Dementia
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COMPLETED
NA
Feasibility of Online Based Mindfulness Interventions During COVID-19 Outbreak
NCT04346082
WITHDRAWN
NA
Mindfulness Training for Psychotherapeutic Care
NCT04680559
COMPLETED
NA
The Effects of an Online Mindfulness-based Intervention for Children with Attention-Deficit/Hyperactivity Disorder
NCT06298136
RECRUITING
NA
The Mechanism of Mindfulness Intervention to Alleviate Emotional Distress in Patients With Emotional Disorders
NCT05891015
NOT_YET_RECRUITING
NA
Examining the Feasibility of a Mindfulness Booster Course for Healthcare Staff Who Attended an 8-week Mindfulness Course
NCT05721716
COMPLETED
NA
The Role of Anchoring and Distraction in the Effectiveness of Mindfulness on Reducing Emotional Reactivity
NCT06876220
COMPLETED
NA
Effects of a Mindfulness Intervention on Temperament, Anxiety and Depression: the Mind the Child Study
NCT05179096
COMPLETED
NA
Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas
NCT07186023
RECRUITING
NA
MINDFUL-PC: Integrating Mindfulness Into the Patient-Centered Medical Home
NCT02972203
COMPLETED
NA
The Role of Cognitive Flexibility in Mindfulness Intervention for Emotional Distress
NCT05806281
UNKNOWN
NA
Mechanisms of Mindfulness Intervention: Distress Tolerance Dose Manipulation
NCT06056232
UNKNOWN
NA