Effects of Mindfulness or Brain Stimulation Intervention for Late-life Adults in Taiwan Urban and Rural Areas

NCT ID: NCT07186023

Last Updated: 2025-09-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

124 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-01

Study Completion Date

2028-12-31

Brief Summary

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This randomized controlled trial will examine the effects of mindfulness-based interventions and brain stimulation interventions on cognitive function and psychological well-being in older adults. The study will employ a comprehensive assessment approach incorporating psychological evaluations, behavioral assessments, psychophysiological measurements, and neuroimaging analyses to characterize the outcome of nonpharmaceutical interventions in improving geriatric well-being or reducing depression severity.

Detailed Description

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Conditions

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Late-Life Adults Late-Life Prodromal Depression Late-Life Depression Mindfulness Brain Stimulation Intervention

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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MBSR

Mindfulness-Based Stress Reduction

Group Type ACTIVE_COMPARATOR

MBSR

Intervention Type BEHAVIORAL

Mindfulness-Based Stress Reduction

MBWC

Mindfulness-Based Well-Being Curriculum

Group Type ACTIVE_COMPARATOR

MBWC

Intervention Type BEHAVIORAL

Mindfulness-Based Well-Being Curriculum

MBCI

Mindfulness-Based Curriculum for Insomnia

Group Type ACTIVE_COMPARATOR

MBCI

Intervention Type BEHAVIORAL

Mindfulness-Based Curriculum for Insomnia

BSI

Brain Stimulation Intervention

Group Type OTHER

BSI

Intervention Type DEVICE

Brain Stimulation Intervention

Interventions

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MBSR

Mindfulness-Based Stress Reduction

Intervention Type BEHAVIORAL

MBWC

Mindfulness-Based Well-Being Curriculum

Intervention Type BEHAVIORAL

MBCI

Mindfulness-Based Curriculum for Insomnia

Intervention Type BEHAVIORAL

BSI

Brain Stimulation Intervention

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Literate or have received an education above the elementary level.
* Have normal or corrected vision and hearing, able to communicate and understand explanations.
* Right-handed individuals as assessed by the Edinburgh Handedness Inventory.


* Individuals diagnosed with major depressive disorder by psychiatrists according to the Diagnostic and Statistical Manual, and who can cooperate with the psychiatric outpatient clinic regulations.
* Literate or have received an education above the elementary level.
* Have normal or corrected vision and hearing, able to communicate and understand explanations.
* Right-handed individuals as assessed by the Edinburgh Handedness Inventory.
* Individuals are prescribed brain stimulation therapy by clinical physicians.

Exclusion Criteria

* Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease.
* Individuals with neurological system disorders.
* Individuals with alcohol or drug dependence.
* Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months.
* Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc.
* Individuals with Claustrophobia.
* Individuals in pregnancy or possibility of pregnancy.


* Individuals with dementia, stroke, cerebrovascular disease, brain injury, epilepsy, or Parkinson's disease.
* Individuals with neurological system disorders.
* Individuals with alcohol or drug dependence.
* Individuals with other major physical illnesses, such as diabetes, heart failure, or endocrine abnormalities, or those who have experienced an acute myocardial infarction within the past three months.
* Individuals with metal objects in the body that cannot undergo magnetic resonance imaging (MRI), such as cardiac pacemakers, vascular clips, hearing aids, artificial joints, steel pins, etc.
* Individuals with Claustrophobia.
* Individuals in pregnancy or possibility of pregnancy.
Minimum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Health Research Institutes, Taiwan

OTHER

Sponsor Role lead

Responsible Party

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Ai-Ling Hsu

Assistant Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Shuang Ho Biomedical Park, Taipei Medical University

New Taipei City, , Taiwan

Site Status RECRUITING

National Center for Geriatrics and Welfare Research

Yunlin, , Taiwan

Site Status NOT_YET_RECRUITING

Countries

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Taiwan

Central Contacts

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Ai-Ling Hsu, PhD.

Role: CONTACT

+886-5-6327369 ext. 143

Changwei W. Wu, PhD.

Role: CONTACT

+886-2-66202589 ext. 10518

Facility Contacts

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Changwei W. Wu, PhD.

Role: primary

+886-2-66202589 ext. 10518

Ai-Ling Hsu, PhD.

Role: primary

+886-5-6327369 ext. 143

Other Identifiers

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CG-114-GP-23

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

EC1140405

Identifier Type: -

Identifier Source: org_study_id

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