Multicenter and Prospective Clinical Registry Study of Anti-N-methyl-D-aspartate Receptor Encephalitis in Beijing Area

NCT ID: NCT02443350

Last Updated: 2015-05-13

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 400 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-06-30

Brief Summary

Anti N-methyl-D-aspartate receptor encephalitis is an autoimmune encephalitis，found in recent years，producing the specific IgG antibody induced by the NMDA receptors.It is the most common curable disease among the non infectious-autoimmune encephalitis,usually has been misdiagnosed as other causes of encephalitis.Our previous study found that there are differences between the Chinese and the foreign in anti-NMDA receptor encephalitis such as the sex ratio, the rate of combined tumor and clinical manifestations.As a new found disease,the incidence rate has been underestimated.Therefore,to establish the Registry Research Database for Chinese group of anti-NMDA receptor encephalitis is imminent.This study will combine Beijing area's hospitals and foreign experts,depending on multicenter, prospective and registry method,to understand the incidence in Beijing area,to summarize and analyze the clinical data of patients.So,there will make a solid foundation for the subsequent Beijing area detection platform and other research.

Conditions

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• Older than 6 months.
• Encephalopathy symptoms (change of mental state and consciousness level) persist for more than 24 hours;
• At least one or more clinical features of the followings: fever, epilepsy, focal neurological deficiency symptoms, changes in CSF(cerebrospinal fluid inflammatory), changes in EEG (electroencephalogram), radiographic abnormalities;
• Clinical suspected encephalitis, but conventional detected methods cannot make etiology clear

Exclusion Criteria

• Infants less than 6 months;
• The metabolic encephalopathy;
• Infectious encephalitis with clinically clear pathogen, referring the specific pathogenic microorganisms, including: bacteria, virus, fungus, parasite, spirochete and so on;
• Non-infectious encephalitis with clinically clear diagnosis, including: multiple sclerosis, optic neuromyelitis, acute disseminated encephalomyelitis and so on.

• Minimum Eligible Age: 6 Months
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Jia Wei Wang,MD

OTHER

Sponsor Role: lead

Responsible Party

Jia Wei Wang,MD

M.D.;The head of Department of Neurology and Medical Research Center

Responsibility Role: SPONSOR_INVESTIGATOR

Locations

Beijing Tongren Hospital,Capital Medical Universiy

Beijing, Beijing Municipality, China

Site Status: RECRUITING

Countries

China

Central Contacts

Jia Wei Wang, M.D

Role: CONTACT

wangjwcq@163.com

(86)010-58268857

Facility Contacts

Jia Wei Wang, M.D

Role: primary

wangjwcq@163.com

(86)15910785840

References

Peng Y, Dai F, Liu L, Chen W, Yan H, Liu A, Zhang X, Wang X, He J, Li Y, Li C, Chen L, Zhao Y, Li L, Ma Q, Wang J. Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis. Neurol Neuroimmunol Neuroinflamm. 2020 Aug 5;7(5):e860. doi: 10.1212/NXI.0000000000000860. Print 2020 Sep.

Reference Type: DERIVED

PMID: 32759178 (View on PubMed)

Other Identifiers

CH 201411101

Identifier Type: -

Identifier Source: org_study_id