Neuro-ophthalmology and Autoimmune Encephalitis (NODE)

NCT ID: NCT03872284

Last Updated: 2025-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-22

Study Completion Date

2020-02-26

Brief Summary

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Autoimmune encephalitis represents a group of rare and heterogeneous neurological disorders. Pathophysiological mechanisms in these diseases are still unknown. Recently, oculomotor and neurovisual disorders have been described. Cerebral areas and neuronal networks associated with these abnormalities are well described. The investigator proposes to study and describe such neuro-ophthalmological disorders in a prospective cohort of patients with a autoimmune encephalitis, to better understand the pathophysiological basis of this neurological condition.

Detailed Description

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Conditions

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Autoimmune Encephalitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Patients in the study group have a diagnosis of autoimmune encephalitis, are 18 to 70 years old, and have no significant comorbidity such as psychiatric, neurological conditions and able to understand the aim of this study.

oculomotor movement recordings, neurovisual assessment

Intervention Type OTHER

Each participant will have a neurovisual assessment and an oculomotor movement recording with an eye tracker (infra red cameras).

Interventions

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oculomotor movement recordings, neurovisual assessment

Each participant will have a neurovisual assessment and an oculomotor movement recording with an eye tracker (infra red cameras).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of autoimmune encephalitis
* With or without pathological antibody
* Aged from 18 to 70 years old
* Able to understand the aims and methods of this project
* Non opposed to the participation of this study

Exclusion Criteria

* Other neurological, psychiatric or systemic conditions, which could induce neuro-ophthalmological signs Cognitive impairment, which is not linked to autoimmune encephalitis
* Ophthalmological condition, which could modify the interpretation of neuro-ophthalmological data Inability to remain seated
* Pregnancy or breast feeding
* Adults under guardianship
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Caroline Tilikete, Prof.

Role: PRINCIPAL_INVESTIGATOR

Department of neuro-ophthalmology, Pierre Wertheimer university hospital

Locations

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Hospices Civils de Lyon

Bron, , France

Site Status

Countries

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France

Other Identifiers

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2019-A00684-53

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL18_0749

Identifier Type: -

Identifier Source: org_study_id

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