Diffusion Imaging in Acute Auto-immune Encephalitis

NCT ID: NCT04339205

Last Updated: 2020-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

80 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-01

Study Completion Date

2020-07-01

Brief Summary

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The aim of this non randomised retrospective study is to investigate the imaging (MRI) of auto-immune encephalitis at presentation, especially in diffusion-weighted sequences.

Indeed, few series describe the MRI aspect of auto-immune at their beginning. Recognize early MRI abnormalities seen in auto-immune encephalitis could help reduce the time to positive diagnosis and improve the therapeutic management.

Detailed Description

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Conditions

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Auto-immune Encephalitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Interventions

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Analysis of every MRI at presentation of the symptoms and then over a period of 3 to 24 months if available.

The radiologist will analyze the MRI of patients with proved auto-immune encephalitis realized at presentation of the symptoms. If available, the following-up MRIs will also be analyzed.

At each assessment, four MRI sequences will be studied : diffusion, T2-weighted, susceptibility sensitive sequences, and T1 weighted after contrast enhanced with gadolinium.

The radiologist will analyse the signal abnormalities, their localisation and the trophicity of the brain.

We will then correlate the following clinical data collected for patients : age, sex, clinical presentation, clinical evolution, and tumor associated or not.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Auto-immune encephalitis proved by biological results (blood and/or CSF sample)

Exclusion Criteria

* No MRI available
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hospices Civils de Lyon

Pierre-Bénite, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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François cotton, phd

Role: CONTACT

04 78 56 91 00

Géraldine PICARD

Role: CONTACT

04 72 35 58 42

Facility Contacts

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François COTTON, PhD

Role: primary

Géraldine PICARD

Role: backup

04 72 35 58 42

Other Identifiers

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Imaging study

Identifier Type: -

Identifier Source: org_study_id

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