FDG-PET in the Diagnosis of Autoimmune Encephalitis

NCT ID: NCT06019975

Last Updated: 2024-01-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

90 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2024-04-30

Brief Summary

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The goal of this retrospective observational study is to compare brain fluorodeoxyglucose-positron emission tomography (FDG-PET) of patients with autoimmune encephalitis, normal controls and patients with Alzheimer's disease (AD). The main question it aims to answer is:

•is there a specific pattern of brain metabolism in patients with autoimmune encephalitis Participants data and images will be retrospectively collected from hospital records, and FDG-PET images will be analyzed by means of statistical parametric mapping (SPM). Controls will be selected from validated public databases.

Detailed Description

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Conditions

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Autoimmune Encephalitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Autoimmune Encephalitis patients

Patients with autoimmune encephalitis admitted to the centers, who underwent a brain FDG-PET during the course of their disease trajectory.

FDG-PET

Intervention Type DIAGNOSTIC_TEST

Brain FDG-PET

Interventions

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FDG-PET

Brain FDG-PET

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of autoimmune encephalitis according to clinical criteria
* Brain magnetic resonance imaging performed between clinical presentation and treatment
* Cerebrospinal fluid analysis performed between clinical presentation and treatment
* Brain FDG-PET performed between clinical presentation and treatment
* Autoantibodies testing performed between clinical presentation and treatment

Exclusion Criteria

* Refusal to give consent for the study
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Milano Bicocca

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Simone Beretta, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Milano Bicocca

Locations

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Azienda Sanitaria Universitaria Friuli Centrale

Udine, Friuli Venezia Giulia, Italy

Site Status NOT_YET_RECRUITING

IRCCS Ospedale Policlinico San Martino

Genoa, Liguria, Italy

Site Status NOT_YET_RECRUITING

Fondazione IRCCS Mondino

Pavia, Lombardy, Italy

Site Status RECRUITING

Fondazione IRCCS San Gerardo dei Tintori

Monza, Monza E Della Brianza, Italy

Site Status RECRUITING

Fondazione IRCCS Istituto Neurologico "Carlo Besta"

Milan, , Italy

Site Status NOT_YET_RECRUITING

Ospedale San Paolo

Milan, , Italy

Site Status NOT_YET_RECRUITING

Countries

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Italy

Central Contacts

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Simone Beretta, MD, PhD

Role: CONTACT

+390392333568

Federico Emanuele Pozzi, MD

Role: CONTACT

Facility Contacts

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Alberto Vogrig, MD, PhD

Role: primary

Flavio Villani, MD

Role: primary

Matteo Gastaldi, MD

Role: primary

Simone Beretta, MD, PhD

Role: primary

+390392333568

Federico Emanuele Pozzi, MD

Role: backup

Francesco Deleo, MD, PhD

Role: primary

Francesco Del Sole, MD, PhD

Role: primary

Other Identifiers

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PEA

Identifier Type: -

Identifier Source: org_study_id

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