A Study of Ramucirumab (LY3009806) Versus Placebo in Participants With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein
NCT ID: NCT02435433
Last Updated: 2023-01-20
Study Results
Results available
Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.
View full resultsBasic Information
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Recruitment Status
COMPLETED
Clinical Phase
PHASE3
Total Enrollment
399 participants
Study Classification
INTERVENTIONAL
Study Start Date
2015-07-20
Study Completion Date
2021-11-19
Brief Summary
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The purpose of this study is to evaluate the safety and efficacy of ramucirumab in participants with hepatocellular carcinoma (HCC) and elevated baseline alpha-fetoprotein. Participants will be randomized to ramucirumab or placebo in a 2:1 ratio (Main Global Cohort and China Maximized Extended Enrollment \[MEE\] Cohort). Participants may also receive ramucirumab if eligible to be enrolled in Open-Label Expansion (OLE) Cohort.
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Detailed Description
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Conditions
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Hepatocellular Carcinoma
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
DOUBLE
Participants
Investigators
Study Groups
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Ramucirumab + Best Supportive Care (BSC)
8 milligrams per kilogram (mg/kg) ramucirumab administered as an intravenous (IV) injection on day 1 of each 14 day cycle. Participants may continue treatment until discontinuation criteria are met.
Group Type
EXPERIMENTAL
Ramucirumab
Intervention Type
DRUG
Administered IV
Placebo + BSC
Placebo administered IV on day 1 of each 14 day cycle. Participants may continue treatment until discontinuation criteria are met.
Group Type
PLACEBO_COMPARATOR
Ramucirumab
Intervention Type
DRUG
Administered IV
Placebo
Intervention Type
DRUG
Administered IV
Open Label Ramucirumab + BSC
8 mg/kg ramucirumab administered IV on day 1 of each 14 day cycle. Participants may continue treatment until discontinuation criteria are met.
Group Type
EXPERIMENTAL
Ramucirumab
Intervention Type
DRUG
Administered IV
Ramucirumab MEE Cohort + BSC
8 mg/kg ramucirumab administered IV on day 1 of each 14 day cycle. Participants may continue treatment until discontinuation criteria are met.
Group Type
EXPERIMENTAL
Ramucirumab
Intervention Type
DRUG
Administered IV
Placebo MEE Cohort + BSC
Placebo administered IV on day 1 of each 14 day cycle. Participants may continue treatment until discontinuation criteria are met.
Group Type
PLACEBO_COMPARATOR
Ramucirumab
Intervention Type
DRUG
Administered IV
Placebo
Intervention Type
DRUG
Administered IV
Interventions
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Ramucirumab
Administered IV
Intervention Type
DRUG
Placebo
Administered IV
Intervention Type
DRUG
Other Intervention Names
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Cyramza
LY3009806
Eligibility Criteria
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Inclusion Criteria
* A diagnosis of HCC based on histopathologic findings, or a diagnosis of cirrhosis and a tumor with classical HCC imaging characteristics.
* Sorafenib was the only systemic therapy for HCC and was discontinued for disease progression or intolerance (Main Global and MEE Cohorts only).
* The participant received ≤2 prior systemic therapy regimen, excluding prior sorafenib or chemotherapy, for the treatment of HCC (OLE Cohort only).
* ≥1 measurable lesion per Response Evaluation Criteria In Solid Tumors (RECIST) Version 1.1 that has not been previously treated with locoregional therapy. A participant with a lesion(s) that has previously been treated with locoregional therapy is also eligible, if the lesion has documented progression after locoregional treatment and is measureable.
* Child-Pugh score \<7 (Child-Pugh Class A).
* Barcelona Clinic Liver Cancer (BCLC) Stage C disease or BCLC Stage B disease not amenable to locoregional therapy or refractory to locoregional therapy.
* Baseline AFP ≥400 nanograms/milliliter.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Resolution of all clinically significant toxic effects of prior therapy.
* Total bilirubin ≤1.5 times upper limit of normal value (ULN), aspartate transaminase (AST) and alanine transaminase (ALT) ≤5 × ULN.
* Creatinine clearance ≥60 milliliters/minute.
* Urinary protein is ≤1+ on dipstick or routine urinalysis or 24-hour urine demonstrating \<1 gram of protein.
* Absolute neutrophil count ≥1.0 × 10\^9/Liter, hemoglobin ≥9 grams/deciliter, and platelets ≥75 × 10\^9/Liter.
* International Normalized Ratio (INR) ≤1.5 and a partial thromboplastin time (PTT) ≤5 seconds above the ULN.
* Surgically sterile, postmenopausal, or compliant with a highly effective contraceptive method.
* If a woman of childbearing potential, a negative serum pregnancy test prior to randomization.
* Willing to provide blood for research. The participant has provided signed informed consent prior to any study specific procedures and is amenable to compliance with protocol schedules and testing.
* Sorafenib was the only systemic therapy for HCC and was discontinued for disease progression or intolerance (Main Global and MEE Cohorts only).
* The participant received ≤2 prior systemic therapy regimen, excluding prior sorafenib or chemotherapy, for the treatment of HCC (OLE Cohort only).
* ≥1 measurable lesion per Response Evaluation Criteria In Solid Tumors (RECIST) Version 1.1 that has not been previously treated with locoregional therapy. A participant with a lesion(s) that has previously been treated with locoregional therapy is also eligible, if the lesion has documented progression after locoregional treatment and is measureable.
* Child-Pugh score \<7 (Child-Pugh Class A).
* Barcelona Clinic Liver Cancer (BCLC) Stage C disease or BCLC Stage B disease not amenable to locoregional therapy or refractory to locoregional therapy.
* Baseline AFP ≥400 nanograms/milliliter.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Resolution of all clinically significant toxic effects of prior therapy.
* Total bilirubin ≤1.5 times upper limit of normal value (ULN), aspartate transaminase (AST) and alanine transaminase (ALT) ≤5 × ULN.
* Creatinine clearance ≥60 milliliters/minute.
* Urinary protein is ≤1+ on dipstick or routine urinalysis or 24-hour urine demonstrating \<1 gram of protein.
* Absolute neutrophil count ≥1.0 × 10\^9/Liter, hemoglobin ≥9 grams/deciliter, and platelets ≥75 × 10\^9/Liter.
* International Normalized Ratio (INR) ≤1.5 and a partial thromboplastin time (PTT) ≤5 seconds above the ULN.
* Surgically sterile, postmenopausal, or compliant with a highly effective contraceptive method.
* If a woman of childbearing potential, a negative serum pregnancy test prior to randomization.
* Willing to provide blood for research. The participant has provided signed informed consent prior to any study specific procedures and is amenable to compliance with protocol schedules and testing.
Exclusion Criteria
* Fibrolamellar carcinoma or mixed hepatocellular cholangiocarcinoma.
* Concurrent malignancy. Participants with carcinoma in situ of any origin and participants with prior malignancies in remission may be eligible with sponsor approval.
* Previous brain metastases, leptomeningeal disease, or uncontrolled spinal cord compression.
* History of or current hepatic encephalopathy or clinically meaningful ascites.
* Ongoing or recent hepatorenal syndrome.
* Liver transplant (Main Global and MEE cohorts only; Participants with prior liver transplant may be eligible for OLE cohort).
* Hepatic locoregional therapy following prior systemic therapy or within 28 days prior to randomization.
* Major surgical procedure, traumatic injury, non-healing wound, or peptic ulcer ≤28 days prior to randomization.
* Received radiation to any nonhepatic (for example, bone) site within 14 days prior to randomization.
* Placement of a subcutaneous venous access device within 7 days prior to the first dose of study treatment unless the procedure is judged of low risk of bleeding.
* Enrolled in a clinical trial involving an investigational product or unapproved use of a drug or in medical research judged not to be scientifically or medically compatible with this study.
* Discontinued from study treatment from another clinical trial within 28 days prior to randomization.
* Known allergy to any of the treatment components.
* Uncontrolled hypertension.
* Any arterial thrombotic event, including myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack, \<6 months prior to randomization.
* Any bleeding episode considered life-threatening, or any Grade 3 or 4 gastrointestinal bleeding episode in the 3 months prior to randomization requiring intervention.
* Esophageal or gastric varices that require intervention or represent high bleeding risk. Participants with evidence of portal hypertension or prior bleeding must have had endoscopic evaluation within 3 months prior to randomization.
* Gastrointestinal perforation or fistulae within 6 months prior to randomization.
* Symptomatic congestive heart failure (New York Heart Association II-IV), unstable angina pectoris, or symptomatic or poorly controlled cardiac arrhythmia.
* Pregnant or breast-feeding.
* Any medical or psychiatric condition that may increase the risk associated with study participation or may interfere with the interpretation of study results. Conditions include but are not limited to:
* Human immunodeficiency virus infection or acquired immunodeficiency syndrome-related illness.
* Active or uncontrolled clinically serious infection. (Participants with chronic viral hepatitis are eligible.)
* Ongoing or recent history of drug abuse.
* Uncontrolled hereditary or acquired thrombotic or bleeding disorder.
* Bowel obstruction, history or presence of inflammatory enteropathy or extensive intestinal resection.
* Therapeutic dose anticoagulation with warfarin, low molecular-weight heparin, or similar agents.
* Chronic therapy with nonsteroidal anti-inflammatory agents or other anti-platelet agents. Aspirin at doses up to 100 milligrams/day is permitted.
* The participant received prior immunotherapy and is experiencing or has experienced any of the following (OLE cohort only):
* Any clinically significant Grade ≥3 immune-related adverse event (irAE)
* Any grade neurologic or ocular irAE
* Any grade immune-related pneumonitis, cardiomyopathy, or hepatitis
* The participant received prior immunotherapy and at the time of study enrollment, requires steroids or other immunosuppressive agents (OLE cohort only).
* Concurrent malignancy. Participants with carcinoma in situ of any origin and participants with prior malignancies in remission may be eligible with sponsor approval.
* Previous brain metastases, leptomeningeal disease, or uncontrolled spinal cord compression.
* History of or current hepatic encephalopathy or clinically meaningful ascites.
* Ongoing or recent hepatorenal syndrome.
* Liver transplant (Main Global and MEE cohorts only; Participants with prior liver transplant may be eligible for OLE cohort).
* Hepatic locoregional therapy following prior systemic therapy or within 28 days prior to randomization.
* Major surgical procedure, traumatic injury, non-healing wound, or peptic ulcer ≤28 days prior to randomization.
* Received radiation to any nonhepatic (for example, bone) site within 14 days prior to randomization.
* Placement of a subcutaneous venous access device within 7 days prior to the first dose of study treatment unless the procedure is judged of low risk of bleeding.
* Enrolled in a clinical trial involving an investigational product or unapproved use of a drug or in medical research judged not to be scientifically or medically compatible with this study.
* Discontinued from study treatment from another clinical trial within 28 days prior to randomization.
* Known allergy to any of the treatment components.
* Uncontrolled hypertension.
* Any arterial thrombotic event, including myocardial infarction, unstable angina, cerebrovascular accident, or transient ischemic attack, \<6 months prior to randomization.
* Any bleeding episode considered life-threatening, or any Grade 3 or 4 gastrointestinal bleeding episode in the 3 months prior to randomization requiring intervention.
* Esophageal or gastric varices that require intervention or represent high bleeding risk. Participants with evidence of portal hypertension or prior bleeding must have had endoscopic evaluation within 3 months prior to randomization.
* Gastrointestinal perforation or fistulae within 6 months prior to randomization.
* Symptomatic congestive heart failure (New York Heart Association II-IV), unstable angina pectoris, or symptomatic or poorly controlled cardiac arrhythmia.
* Pregnant or breast-feeding.
* Any medical or psychiatric condition that may increase the risk associated with study participation or may interfere with the interpretation of study results. Conditions include but are not limited to:
* Human immunodeficiency virus infection or acquired immunodeficiency syndrome-related illness.
* Active or uncontrolled clinically serious infection. (Participants with chronic viral hepatitis are eligible.)
* Ongoing or recent history of drug abuse.
* Uncontrolled hereditary or acquired thrombotic or bleeding disorder.
* Bowel obstruction, history or presence of inflammatory enteropathy or extensive intestinal resection.
* Therapeutic dose anticoagulation with warfarin, low molecular-weight heparin, or similar agents.
* Chronic therapy with nonsteroidal anti-inflammatory agents or other anti-platelet agents. Aspirin at doses up to 100 milligrams/day is permitted.
* The participant received prior immunotherapy and is experiencing or has experienced any of the following (OLE cohort only):
* Any clinically significant Grade ≥3 immune-related adverse event (irAE)
* Any grade neurologic or ocular irAE
* Any grade immune-related pneumonitis, cardiomyopathy, or hepatitis
* The participant received prior immunotherapy and at the time of study enrollment, requires steroids or other immunosuppressive agents (OLE cohort only).
Minimum Eligible Age
18 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Eli Lilly and Company
INDUSTRY
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern Time (UTC/GMT - 5 hours EST)
Role: STUDY_DIRECTOR
Eli Lilly and Company
Locations
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Pacific Hematology and Oncology Associates
Daly City, California, United States
Site Status
UCLA Medical Center
Los Angeles, California, United States
Site Status
Georgetown University Medical Center
Washington D.C., District of Columbia, United States
Site Status
University of Iowa Hospital
Iowa City, Iowa, United States
Site Status
Massachusetts General Hospital
Boston, Massachusetts, United States
Site Status
Mount Sinai Medical Center
New York, New York, United States
Site Status
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma, United States
Site Status
OREGON HEALTH and SCIENCE UNIVERSITY
Portland, Oregon, United States
Site Status
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Kurralta Park, , Australia
Site Status
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Woodville, , Australia
Site Status
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Linz, , Austria
Site Status
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Vienna, , Austria
Site Status
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Brussels, , Belgium
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Liège, , Belgium
Site Status
Fundação PIO XII
Barretos, , Brazil
Site Status
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Barretos, , Brazil
Site Status
Cenantron - Centro Avançado de Tratamento Oncológico
Belo Horizonte, , Brazil
Site Status
Associação Hospital de Caridade Ijuí
Ijuí, , Brazil
Site Status
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Porto Alegre, , Brazil
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São Paulo, , Brazil
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Montreal, , Canada
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Toronto, , Canada
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Beijing, , China
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Beijing, , China
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Beijing, , China
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Beijing, , China
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Changsha, , China
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Changsha, , China
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Chongqing, , China
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Guangdong, , China
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Guangzhou, , China
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Hangzhou, , China
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Hangzhou, , China
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Hangzhou, , China
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Hebei, , China
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Hefei, , China
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Heilongjiang, , China
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Henan, , China
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Hubei, , China
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Nanjing, , China
Site Status
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Nanjing, , China
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Nanning, , China
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Qingdao, , China
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Shanghai, , China
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Shanghai, , China
Site Status
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Shanghai, , China
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Shanghai, , China
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Shenyang, , China
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Wuhan, , China
Site Status
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Xi'an, , China
Site Status
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Brno, , Czechia
Site Status
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Prague, , Czechia
Site Status
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Amiens, , France
Site Status
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Avignon, , France
Site Status
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Besançon, , France
Site Status
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Caen, , France
Site Status
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Clermont-Ferrand, , France
Site Status
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Lyon, , France
Site Status
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Montpellier, , France
Site Status
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Nantes, , France
Site Status
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Pessac, , France
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Rennes, , France
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Saint-Etienne, , France
Site Status
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Bayern, , Germany
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Berlin, , Germany
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Essen, , Germany
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Frankfurt, , Germany
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Hamburg, , Germany
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Hanover, , Germany
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Leipzig, , Germany
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Magdeburg, , Germany
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Mainz, , Germany
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München, , Germany
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Tübingen, , Germany
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Hong Kong, , Hong Kong
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Hong Kong, , Hong Kong
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Kowloon, , Hong Kong
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Shatin, , Hong Kong
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Tuenmen, , Hong Kong
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Haifa, , Israel
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Tel Aviv, , Israel
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Benevento, , Italy
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Bologna, , Italy
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Cremona, , Italy
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Padua, , Italy
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Rome, , Italy
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Chūōku, , Japan
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Fukuoka, , Japan
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Fukuoka, , Japan
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Iizuka, , Japan
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Kanazawa, , Japan
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Kashiwa, , Japan
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Kyoto, , Japan
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Matsuyama, , Japan
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Osaka, , Japan
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Ōsaka, , Japan
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Shimotsuke, , Japan
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Suita-shi, , Japan
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Sunto-Gun, , Japan
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Tokyo, , Japan
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Yokohama, , Japan
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Gdansk, , Poland
Site Status
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Poznan, , Poland
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Warsaw, , Poland
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Incheon, , South Korea
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Seoul, , South Korea
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Seoul, , South Korea
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Seoul, , South Korea
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Seoul, , South Korea
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Ulsan, , South Korea
Site Status
Hospital Universitari de Girona Dr. Josep Trueta
Girona, , Spain
Site Status
Hospital Clínico San Carlos
Madrid, , Spain
Site Status
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Santander, , Spain
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Valencia, , Spain
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Bern, , Switzerland
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Buzi, , Taiwan
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Kaohsiung City, , Taiwan
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Taichung, , Taiwan
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Tainan City, , Taiwan
Site Status
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Tainan City, , Taiwan
Site Status
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Tainan City, , Taiwan
Site Status
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Taipei, , Taiwan
Site Status
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Taipei, , Taiwan
Site Status
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Taoyuan, , Taiwan
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Acton, , United Kingdom
Site Status
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Acton, , United Kingdom
Site Status
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Bebington, , United Kingdom
Site Status
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Birmingham, , United Kingdom
Site Status
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London, , United Kingdom
Site Status
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London, , United Kingdom
Site Status
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Manchester, , United Kingdom
Site Status
Countries
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United States
Australia
Austria
Belgium
Brazil
Canada
China
Czechia
France
Germany
Hong Kong
Israel
Italy
Japan
Poland
South Korea
Spain
Switzerland
Taiwan
United Kingdom
References
Explore related publications, articles, or registry entries linked to this study.
Shao G, Bai Y, Yuan X, Chen X, Gu S, Gu K, Hu C, Liang H, Guo Y, Wang J, Yen CJ, Lee VH, Wang C, Widau RC, Zhang W, Liu J, Zhang Q, Qin S. Ramucirumab as second-line treatment in Chinese patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein after sorafenib (REACH-2 China): A randomised, multicentre, double-blind study. EClinicalMedicine. 2022 Oct 6;54:101679. doi: 10.1016/j.eclinm.2022.101679. eCollection 2022 Dec.
Reference Type
DERIVED
Llovet JM, Singal AG, Villanueva A, Finn RS, Kudo M, Galle PR, Ikeda M, Callies S, McGrath LM, Wang C, Abada P, Widau RC, Gonzalez-Gugel E, Zhu AX. Prognostic and Predictive Factors in Patients with Advanced HCC and Elevated Alpha-Fetoprotein Treated with Ramucirumab in Two Randomized Phase III Trials. Clin Cancer Res. 2022 Jun 1;28(11):2297-2305. doi: 10.1158/1078-0432.CCR-21-4000.
Reference Type
DERIVED
Mitani S, Chen Y, Inoue K, Mori J, Gao L, Long A, Wakabayashi S. Clinical Impact of a Shortened Infusion Duration of Ramucirumab in Japanese Patients -A Model-Based Approach. Gan To Kagaku Ryoho. 2021 Nov;48(11):1381-1387.
Reference Type
DERIVED
Trojan J, Mollon P, Daniele B, Marteau F, Martin L, Li Y, Xu Q, Piscaglia F, Zaucha R, Sarker D, Lim HY, Venerito M. Comparative Efficacy of Cabozantinib and Ramucirumab After Sorafenib for Patients with Hepatocellular Carcinoma and Alpha-fetoprotein >/= 400 ng/mL: A Matching-Adjusted Indirect Comparison. Adv Ther. 2021 May;38(5):2472-2490. doi: 10.1007/s12325-021-01700-2. Epub 2021 Apr 6.
Reference Type
DERIVED
Zhu AX, Finn RS, Kang YK, Yen CJ, Galle PR, Llovet JM, Assenat E, Brandi G, Motomura K, Ohno I, Daniele B, Vogel A, Yamashita T, Hsu CH, Gerken G, Bilbruck J, Hsu Y, Liang K, Widau RC, Wang C, Abada P, Kudo M. Serum alpha-fetoprotein and clinical outcomes in patients with advanced hepatocellular carcinoma treated with ramucirumab. Br J Cancer. 2021 Apr;124(8):1388-1397. doi: 10.1038/s41416-021-01260-w. Epub 2021 Feb 3.
Reference Type
DERIVED
Reig M, Galle PR, Kudo M, Finn R, Llovet JM, Metti AL, Schelman WR, Liang K, Wang C, Widau RC, Abada P, Zhu AX. Pattern of progression in advanced hepatocellular carcinoma treated with ramucirumab. Liver Int. 2021 Mar;41(3):598-607. doi: 10.1111/liv.14731. Epub 2020 Dec 5.
Reference Type
DERIVED
Zhu AX, Nipp RD, Finn RS, Galle PR, Llovet JM, Blanc JF, Okusaka T, Chau I, Cella D, Girvan A, Gable J, Bowman L, Wang C, Hsu Y, Abada PB, Kudo M. Ramucirumab in the second-line for patients with hepatocellular carcinoma and elevated alpha-fetoprotein: patient-reported outcomes across two randomised clinical trials. ESMO Open. 2020 Aug;5(4):e000797. doi: 10.1136/esmoopen-2020-000797.
Reference Type
DERIVED
Kudo M, Okusaka T, Motomura K, Ohno I, Morimoto M, Seo S, Wada Y, Sato S, Yamashita T, Furukawa M, Aramaki T, Nadano S, Ohkawa K, Fujii H, Kudo T, Furuse J, Takai H, Homma G, Yoshikawa R, Zhu AX. Ramucirumab after prior sorafenib in patients with advanced hepatocellular carcinoma and elevated alpha-fetoprotein: Japanese subgroup analysis of the REACH-2 trial. J Gastroenterol. 2020 Jun;55(6):627-639. doi: 10.1007/s00535-020-01668-w. Epub 2020 Feb 27.
Reference Type
DERIVED
Zhu AX, Kang YK, Yen CJ, Finn RS, Galle PR, Llovet JM, Assenat E, Brandi G, Pracht M, Lim HY, Rau KM, Motomura K, Ohno I, Merle P, Daniele B, Shin DB, Gerken G, Borg C, Hiriart JB, Okusaka T, Morimoto M, Hsu Y, Abada PB, Kudo M; REACH-2 study investigators. Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased alpha-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2019 Feb;20(2):282-296. doi: 10.1016/S1470-2045(18)30937-9. Epub 2019 Jan 18.
Reference Type
DERIVED
Provided Documents
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Document Type: Study Protocol
Document Type: Statistical Analysis Plan
Related Links
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https://trials.lillytrialguide.com/en-US/trial/12euK0N4aQe2aiGqC6GEQ4
A Study of Ramucirumab (LY3009806) Versus Placebo in Participants With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein
Other Identifiers
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I4T-MC-JVDE
Identifier Type: OTHER
Identifier Source: secondary_id
2014-005068-13
Identifier Type: EUDRACT_NUMBER
Identifier Source: secondary_id
15755
Identifier Type: -
Identifier Source: org_study_id
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NCT01008566
COMPLETED
PHASE1
Study of Pembrolizumab (MK-3475) or Placebo Given With Best Supportive Care in Asian Participants With Previously Treated Advanced Hepatocellular Carcinoma (MK-3475-394/KEYNOTE-394)
NCT03062358
COMPLETED
PHASE3
Radomised Phase II Study of MTL-CEBPA Plus Sorafenib or Sorafenib Alone
NCT04710641
COMPLETED
PHASE2
Sorafenib With BIIB022 in Hepatocellular Carcinoma (HCC)
NCT00956436
COMPLETED
PHASE1
Chemoembolization With or Without Sorafenib Tosylate in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
NCT01004978
COMPLETED
PHASE3
Study of Pembrolizumab (MK-3475) vs. Best Supportive Care in Participants With Previously Systemically Treated Advanced Hepatocellular Carcinoma (MK-3475-240/KEYNOTE-240)
NCT02702401
COMPLETED
PHASE3
Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma
NCT05359861
COMPLETED
PHASE2
Ezurpimtrostat Autophagy Inhibitor in Association With Atezolizumab-Bevacizumab in First Line Treatment of Unresectable Hepatocellular Carcinoma
NCT05448677
TERMINATED
PHASE2
The Efficacy of 5-fluorouracil/Mitomycin for the Patients With Pulmonary Metastasis of Hepatocellular Carcinoma
NCT01953406
WITHDRAWN
PHASE2
A Study of LY2157299 in Participants With Advanced Hepatocellular Carcinoma
NCT02178358
COMPLETED
PHASE2
Study of Regorafenib After Sorafenib in Patients With Hepatocellular Carcinoma
NCT01774344
COMPLETED
PHASE3