A Study to Evaluate the Safety and Tolerability of Lenvatinib in Participants With Advanced or Unresectable Hepatocellular Carcinoma

NCT ID: NCT04763408

Last Updated: 2024-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

335 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-09

Study Completion Date

2023-12-13

Brief Summary

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The primary purpose of this study is to further characterise the hepatotoxicity in participants with advanced or unresectable hepatocellular carcinoma (HCC) treated with lenvatinib, and to further characterise the overall safety profile (serious adverse events \[SAEs\], grade 3 to 5 adverse events \[AEs\], dose modifications and discontinuations due to AEs) in participants with advanced or unresectable HCC treated with lenvatinib.

Detailed Description

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Conditions

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Carcinoma, Hepatocellular

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Lenvatinib

Participants with advanced or unresectable HCC will initiate treatment with lenvatinib capsules based on physicians decision and will be observed until withdrawal of consent, loss to follow-up, death or until the end of the study (up to 7 years) whichever occurs first.

Lenvatinib

Intervention Type DRUG

Oral capsules.

Sorafenib

Participants with advanced or unresectable HCC will initiate treatment with sorafenib tablets based on physicians decision and will be observed until withdrawal of consent, loss to follow-up, death or until the end of the study (up to 7 years) whichever occurs first.

Sorafenib

Intervention Type DRUG

Oral tablets.

Interventions

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Lenvatinib

Oral capsules.

Intervention Type DRUG

Sorafenib

Oral tablets.

Intervention Type DRUG

Other Intervention Names

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Lenvima E7080

Eligibility Criteria

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Inclusion Criteria

1. Participants with advanced or unresectable HCC for whom a decision has been made by the treating physician (at their discretion) to initiate lenvatinib or sorafenib treatment, within the prescribing conditions of the approved product label
2. Participants must provide signed informed consent to participate in the study within 31 days of initiating treatment with lenvatinib or sorafenib

Exclusion Criteria

None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eisai Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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California Liver Research Institute

Pasadena, California, United States

Site Status

Montefiore Medical Center

The Bronx, New York, United States

Site Status

University of Texas Southwestern Medical Center

Dallas, Texas, United States

Site Status

Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

Site Status

Liverpool Hospital

Liverpool, New South Wales, Australia

Site Status

Monash Health, Monash Medical Centre

Clayton, Victoria, Australia

Site Status

Universitätsklinikum Innsbruck

Innsbruck, Tyrol, Austria

Site Status

Klinikum Klagenfurt Am Woerthersee

Klagenfurt, , Austria

Site Status

Universitätsklinikum St. Pölten

Sankt Pölten, , Austria

Site Status

Medizinische Universitat Wien (Medical University of Vienna)

Vienna, , Austria

Site Status

Eisai Trial Site #3

Cologne, North Rhine-Westphalia, Germany

Site Status

Eisai Trial Site #5

Mainz, Rhineland-Palatinate, Germany

Site Status

Eisai Trial Site #2

Berlin, , Germany

Site Status

Eisai Trial Site #6

Munich, , Germany

Site Status

Eisai Trial Site #1

Ulm, , Germany

Site Status

Ospedale del Mare

Napoli, Campania, Italy

Site Status

Fondazione PTV Policlinico Tor Vergata

Rome, Lazio, Italy

Site Status

Azienda Ospedaliera San Camillo Forlanini

Rome, Lazio, Italy

Site Status

Fondazione Policlinico Universitario A Gemelli

Rome, Lazio, Italy

Site Status

Azienda Ospedaliero Universitaria Di Cagliari

Monserrato Cagliari, Sardinia, Italy

Site Status

Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi

Bologna, , Italy

Site Status

Hospital Garcia de Orta

Almada, Setúbal District, Portugal

Site Status

Instituto Português de Oncologia Francisco Gentil Centro Regional de Oncologia de Coimbra EPE

Coimbra, , Portugal

Site Status

Centro Hospitalar Lisboa Norte, E.P.E. - Hospital de Santa Maria

Lisbon, , Portugal

Site Status

Centro Hospitalar Trás Os Montes E Alto Douro EPE

Vila Real, , Portugal

Site Status

Budgetary Institution of the Chuvash Republic-The Republican Clinical Oncologic Dispensary-Cheboksar

Cheboksary, Chuvashskaya Respublika, Russia

Site Status

Corporacio Sanitaria Parc Tauli

Sabadell, Barcelona, Spain

Site Status

Hospital Universitario Marques de Valdecilla

Santander, Cantabria, Spain

Site Status

Hospital Universitario Virgen de La Arrixaca

El Palmar, Murcia, Spain

Site Status

Hospital General Universitario de Alicante

Alicante, , Spain

Site Status

C.H. Regional Reina Sofia - PPDS

Córdoba, , Spain

Site Status

Hospital Universitario de Getafe

Getafe, , Spain

Site Status

Hospital Universitario Ramon y Cajal

Madrid, , Spain

Site Status

Hospital Regional Universitario de Malaga - Hospital General

Málaga, , Spain

Site Status

CHUS - H. Clinico U. de Santiago

Santiago de Compostela, , Spain

Site Status

Hospital Universitario Virgen del Rocio - PPDS

Seville, , Spain

Site Status

Hospital Universitari i Politecnic La Fe de Valencia

Valencia, , Spain

Site Status

Hospital Clinico Universitario Lozano Blesa

Zaragoza, , Spain

Site Status

Hospital Universitario Miguel Servet

Zaragoza, , Spain

Site Status

Karolinska Universitetssjukhuset Huddinge

Stockholm, , Sweden

Site Status

University Hospitals Birmingham NHS Foundation Trust

Birmingham, , United Kingdom

Site Status

Barts Health NHS Trust - Charterhouse Square

London, , United Kingdom

Site Status

Royal Free London NHS Foundation Trust

London, , United Kingdom

Site Status

Nottingham University Hospitals NHS Trust

Nottingham, , United Kingdom

Site Status

Countries

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United States Australia Austria Germany Italy Portugal Russia Spain Sweden United Kingdom

Other Identifiers

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E7080-M000-508

Identifier Type: -

Identifier Source: org_study_id

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