Explore the Association Between Neuropsychological Functions and ADHD Diagnosis and Comorbid Using Longitudinal Study in Preschool Children

NCT ID: NCT02433145

Last Updated: 2015-05-04

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 220 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-10-31
• Study Completion Date: 2017-08-31

Brief Summary

The current study using the longitudinal study in preschool children to exam three study issues: 1) using the neuropsychological functions (ie. Behavioral inhibition, delay aversion, the variability of reaction time) among the preschool children predict the ADHD diagnosis and behavior symptoms in 1.5 years later. 2) using the behavior inhibition, delay aversion and the variability of reaction time (using the parameter among Gaussian distribution and ex-Gaussian distribution) explore the association between attention and motor inhibition problems. 3) explore the transaction effect between the neuropsychological functions and family function and parenting to predict ADHD comorbidity with oppositional defiant disorder.4) explore the association between the internalizing/ externalizing problems of ADHD and temperament. The current study has opportunity to describe and to answer the complicated problems for heterogeneous neuropsychological deficits in ADHD, and to elucidate the core issues for ADHD have comorbid with ODD. The most important contribution is to offer the empirical evidence to make a clean suggestion in ADHD diagnosis and intervention in preschool age.

Detailed Description

The current study would follow the same participants for 1.5 years, time 1 is around 4-5 years old, and time 2 is around 6-7 years old.

Participants:

• 100 typical developmental control
• 120 ADHD high risk preschool children at time 1

The diagnosis at time 2 to have three groups in this study:

• ADHD persistent
• ADHD remission
• typical developmental control

The measurements were included

• the different neuropsychological test (ie. behavioral inhibition, delay aversion, and vigilance task)
• the ADHD behavioral rating scales and diagnosis interview
• the scaling for family function and parenting
• intellectual assessment

This study could offer the suggestion for the further intervention in ADHD.

Conditions

Attention Deficit/Hyperactivity Disorder

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Control group

• The subjects without ADHD.
• Ages range from 4 to 5
• Full scale IQ ≥ 80
• The subjects who and whose parents consent to this study.

2. ADHD high risk group

• Patients who have clinically diagnosis of DSM-IV ADHD confirmed by the Psychiatrists or have the risk of becoming ADHD confirmed by the ADHD behavioral rating scales.
• Ages range from 4 to 5
• Full scale IQ ≥ 80
• Patients who and whose parents consent to this study.

Exclusion Criteria

• Mental Retardation
• Schizophrenia, Schizoaffective Disorder
• Mood Disorders
• Organic Psychosis
• Learning Disorder
• Pervasive Developmental Disorder

• Minimum Eligible Age: 4 Years
• Maximum Eligible Age: 5 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Susan Shur-Fen Gau, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

National Taiwan University Hospital

Taipei, , Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Susan Shur-Fen Gau, MD, PhD

Role: CONTACT

gaushufe@ntu.edu.tw

02-23123456 ext. 66802

Facility Contacts

Susan Shur-Fen Gau, MD, PhD

Role: primary

gaushufe@ntu.edu.tw

02-23123456 ext. 66802

Other Identifiers

201405086RINB

Identifier Type: -

Identifier Source: org_study_id