Brain Activity in Adults With ADHD During Neuropsychological Tasks
NCT ID: NCT02578342
Last Updated: 2022-04-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
45 participants
OBSERVATIONAL
2015-08-31
2020-11-30
Brief Summary
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Detailed Description
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The aim of the study is to investigate the response on cognitive testing of healthy persons compared to adults with or without medication against ADHD. As a secondary endpoint a more robust diagnosing method combining advanced imaging methods with neuropsychological evaluation is tested.
Neuropsychological testing, functional MRI and spectroscopy will be performed. Statistical analysis will assess differences in the functional magnetic resonance imaging, spectroscopy and neuropsychological evaluation results between three groups: 1) group of healthy volunteers, 2) participants with ADHD with medication and 3) participants with ADHD without medication.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Healthy volunteers
healthy volunteer between age of 20 to 55 will undergo MRI examination.
MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
ADHD subjects without medication
Medication-naive subjects with ADHD (20-55 years) will undergo MRI examination.
MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
ADHD subjects with medication
Subjects with ADHD (20-55 years), under medication will undergo MRI examination.
MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
Interventions
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MRI
Functional Magnetic Resonance Imaging technique measures brain activity by detecting associated changes in blood oxygenation level dependency
Eligibility Criteria
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Inclusion Criteria
* Participant is not pregnant
Exclusion Criteria
* Suspected or proven pregnancy
* Nursing
* Neurological diseases that could interfere with a diagnosis of ADHD
* Psychiatric comorbidity under treatment
* Previous history of psychiatric medication
* Substance abuse
* Intelligence quotient\<75
* Claustrophobia
* Electrical simulator nerve or bone
* Implanted medication infusion pump
* Cerebral aneurysm clips
* Unstable medical condition
20 Years
55 Years
ALL
Yes
Sponsors
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Kantonsspital Aarau
OTHER
Responsible Party
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Luca Remonda
Prof. Dr. med.
Locations
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Kantonsspital Aarau
Aarau, Canton of Aargau, Switzerland
Countries
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References
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Berberat J, Huggenberger R, Montali M, Gruber P, Pircher A, Lovblad KO, Killer HE, Remonda L. Brain activation patterns in medicated versus medication-naive adults with attention-deficit hyperactivity disorder during fMRI tasks of motor inhibition and cognitive switching. BMC Med Imaging. 2021 Mar 19;21(1):53. doi: 10.1186/s12880-021-00579-3.
Other Identifiers
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1410.000.055
Identifier Type: -
Identifier Source: org_study_id
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