Prevalence and Predictors of Depression in COPD

NCT ID: NCT02415140

Last Updated: 2015-04-14

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 161 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2013-10-31

Brief Summary

Depression adversely affects quality of life in COPD patients, associated with higher rate of exacerbations, admissions and mortality. However, local prevalence rate of depression in geriatric COPD patients remains unknown.

Though BODE index is superior to FEV1 in prediction of depression in COPD, it is unclear which domain of BODE correlates best with depression. Furthermore, with multiple confounding factors, it's ambiguous that whether frequent exacerbation is an 'independent' predictor for depression among COPD patients.

The objective of this study is i.) to study the local prevalence rate of depression in geriatric COPD patients, ii.) to identify risk factors for depression especially looking at the any independent relationship between frequent exacerbations, various domains of BODE index and depression.

Detailed Description

This study is a multi-centers, cross-sectional study, conducted in Kwong Wah Hospital and Wong Tai Sin Hospital, Hong Kong SAR. Age and comorbidity-matched COPD and control subjects were recruited from clinics. Depressive symptoms were measured by a validated Chinese version of Geriatric Depression Scale short form (GDS - 15 items) with 2 cut-off points. A score of 8 or above was considered significant depressive symptoms while the cut off score of 5 or above was for patients with mild depressive symptoms. Prevalence rates of depressive symptoms were measured in both COPD and control groups. Predictors for depression (GDS = or> 8) were determined using univariate and multivariate analysis.

Conditions

Depression; COPD

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

COPD

Spirometry confirmed COPD patients

Rate of depression

Intervention Type: OTHER

Control

normal geriatric patients without lung disease

Rate of depression

Intervention Type: OTHER

Interventions

Rate of depression

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• aged 60 or above,
• with stable COPD suggested clinically and
• post-bronchodilator spirometry FEV1/FVC ratio <0.7.

Exclusion Criteria

• Patients were excluded if they had co-existing pulmonary diseases like active pulmonary tuberculosis, interstitial lung diseases etc;
• if they were too demented or physically incapacitated to participate e.g wheelchair-bound for bedbound.

• Minimum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Kwong Wah Hospital

OTHER

Sponsor Role: lead

Responsible Party

Tse Hoi Nam

Associate Consultant

Responsibility Role: PRINCIPAL_INVESTIGATOR

Other Identifiers

KW/EX-13-142 (70-02)

Identifier Type: -

Identifier Source: org_study_id