The Hasselt APPendicitis Immunology and Environmental Cohort STudy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

308 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-06-30

Study Completion Date

2018-10-31

Brief Summary

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The Hasselt Appendicitis Immunology and Environmental Study (HAPPIEST) aims at characterizing factors that influence the development and severity of acute appendicitis. In a cohort of 300 patients and 300 controls, environmental factors as well as genetic make-up of the innate immune system, focusing mainly on pattern recognition, will be analyzed in order to gain insight in their relative importance in the pathology of appendicitis. Furthermore, populations of micro-organisms present in the gut of patients will be characterized, and the interaction between relevant micro-organisms and the innate immune system will be analyzed.

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Detailed Description

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Conditions

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Appendicitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Appendicitis patients

Patients presenting with acute appendicitis

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Acute appendicitis
* Appendectomy within 7 days after onset of symptoms
* Signed informed consent

Exclusion Criteria

* Appendectomy 7 days or more after onset of symptoms
* Participation in any clinical investigational drug study within 4 weeks of screening
* Severe, life-threatening disease with a life expectancy of less than 2 months.

Minimum Eligible Age

5 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes