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CRP /albumin Ratio and Neutrophil Lymphocyte Ratio in Predicting Activity in IBD Patients

NCT ID: NCT06750315

Last Updated: 2024-12-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

35 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-01-01

Study Completion Date

2025-12-01

Brief Summary

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This study aimed to assess the clinical utility of the NLR (neutrophil lymphocyte ratio) and CRP Albumin ratio in predicting activity of IBD Patients in assiut university

Detailed Description

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IBD definition term for two conditions (Crohn\'s disease and ulcerative colitis) is a chronic idiopathic inflammatory disease affecting the large intestine. It is characterized by relapsing mucosal inflammation. The aim of treatment is to induce and maintain disease remission. Assessing disease activity may help in optimizing the management of IBD patients.

The neutrophil-to-lymphocyte ratio (NLR) is a simple index that can be calculated from the results of ordinary blood tests; it is calculated from a blood sample by dividing the absolute neutrophil count by the absolute lymphocyte count . As the NLR can reflect the systemic status of inflammation or immune response.

The underlying mechanism that the NLR was a predictor of clinilcal relapse in UC patients with Mucosal healing remains poorly understood. Neutrophils induce cytotoxicity and inflammation in UC. A high NLR value may be due to high activity in UC and lowered mucosal barrier function, which may lead to the migration of neutrophils through the gut microbiota .

CRP is routinely used as a surrogate measure of intestinal inflammation and as a prognostic measure of nonresponse to medical therapy and colectomy in patients with IBD.

Conditions

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Inflammatory Bowel Disease (IBD)

Keywords

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CRP/ALB ratio N/L ratio

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

Patients more than 18 years newly diagnosed as IBD

\-

Exclusion Criteria

* Patients Not DM Not cardiac failure Not Liver failure No malignancy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Assiut University

OTHER

Sponsor Role lead

Responsible Party

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Amira Mohamed Ali Ahmed

Assistant Lecturer

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Assiut University

Asyut, , Egypt

Site Status

Assiut university hospital

Egypt, Assiut, , Egypt

Site Status

Countries

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Egypt

Central Contacts

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Amira Mohamed Ali Ahmed

Role: CONTACT

Phone: 01090176978

Email: [email protected]

Facility Contacts

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Assiut university hospital Albumin Creatinine ratio and N/L ratio in active IBD patients

Role: primary

Assiut university hospital Albumin Creatinine ratio and N/L ratio in active IBD patients

Role: primary

References

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Torun S, Tunc BD, Suvak B, Yildiz H, Tas A, Sayilir A, Ozderin YO, Beyazit Y, Kayacetin E. Assessment of neutrophil-lymphocyte ratio in ulcerative colitis: a promising marker in predicting disease severity. Clin Res Hepatol Gastroenterol. 2012 Oct;36(5):491-7. doi: 10.1016/j.clinre.2012.06.004. Epub 2012 Jul 27.

Reference Type BACKGROUND
PMID: 22841412 (View on PubMed)

Nguyen AL, Brick C, Liu D, Gibson DJ, Gibson PR, Sparrow MP. Clinical utility of C-reactive protein-to-albumin ratio in the management of patients with inflammatory bowel disease. JGH Open. 2024 Apr 15;8(4):e13059. doi: 10.1002/jgh3.13059. eCollection 2024 Apr.

Reference Type BACKGROUND
PMID: 38623491 (View on PubMed)

Demir AK, Demirtas A, Kaya SU, Tastan I, Butun I, Sagcan M, Sahin S, Tasliyurt T, Yilmaz A. The relationship between the neutrophil-lymphocyte ratio and disease activity in patients with ulcerative colitis. Kaohsiung J Med Sci. 2015 Nov;31(11):585-90. doi: 10.1016/j.kjms.2015.10.001. Epub 2015 Oct 31.

Reference Type BACKGROUND
PMID: 26678939 (View on PubMed)

Langley BO, Guedry SE, Goldenberg JZ, Hanes DA, Beardsley JA, Ryan JJ. Inflammatory Bowel Disease and Neutrophil-Lymphocyte Ratio: A Systematic Scoping Review. J Clin Med. 2021 Sep 17;10(18):4219. doi: 10.3390/jcm10184219.

Reference Type BACKGROUND
PMID: 34575330 (View on PubMed)

Other Identifiers

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CRP/ALB and N/L In active IBD

Identifier Type: -

Identifier Source: org_study_id