Epithelial Dysmetabolism and Renal Fibrosis in ANCA Vasculitis

NCT ID: NCT07010250

Last Updated: 2025-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

146 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-06-02

Study Completion Date

2029-06-02

Brief Summary

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The project is to explore in humans the hypothesis of the link between the alteration of tubulo-interstitial metabolism and the rate of deterioration of renal function by comparing various nephropathies.

Detailed Description

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Patients with ANCA vasculitis with rapidly progressive glomerulonephritis with "crescent" will be compared to six other groups made up of patients with another nephropathy 1/extramembranous glomerulonephritis and 2/ nephropathy with minimal glomerular lesion (LGM) characterized by the absence of significant tubulointerstitial fibrosis lesions and slow evolution towards end-stage chronic renal failure ). Other groups of patients will 3/have interstitial nephropathy, 4/IgA mesangial glomerulopathy , 5/diabetic nephropathy, or 6/collapsing focal segmental hyalinosis.

Conditions

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ANCA Associated Vasculitis Extramembranous Glomerulopathy Nephrotic Syndrome, Minimal Change Interstitial Nephritis IgA Nephropathy Segmental Hyalinosis Diabetic Nephropathies

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ANCA Associated Vasculitis

Case

No interventions assigned to this group

Extramembranous Glomerulopathy

Control

No interventions assigned to this group

Nephrotic Syndrome, Minimal Change

Control

No interventions assigned to this group

Interstitial Nephritis

Control

No interventions assigned to this group

IgA Nephropathy

Control

No interventions assigned to this group

Segmental Hyalinosis

Control

No interventions assigned to this group

Diabetic Nephropathy

Control

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with an indication for initial diagnostic PBR on native kidney
* 18 ans ≥ Age ≤ 90 ans
* Affiliation to french health insurance
* Patient having given consent

For the ANCA vasculitis group:

• Diagnosis of ANCA vasculitis retained on renal biopsy with ANCA anti-proteinase 3 (PR3) or ANCA anti-myeloperoxidase (MPO)

For the control groups:

• Diagnosis retained after the renal biopsy

* Interstitial Nephritis
* Or glomerular nephropathy such as minimal change nephropathy
* Or Segmental hyalinosis in itscollapsing form
* Or Extramembranous Glomerulopathy,
* Or glomerulopathy with mesangial IgA deposits
* Or diabetic nephropathy.

Exclusion Criteria

* Kidney transplant patient
* Patient on dialysis (hemodialysis or peritoneal dialysis)
* Patient under legal protection, guardianship or curatorship
* Pregnancy or breastfeeding
* Enrollement in an interventional study except studies relating to ANCA vasculitis and nephropathy with mesangial IgA deposits.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Ministry of Health, France

OTHER_GOV

Sponsor Role collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role collaborator

National Research Agency, France

OTHER

Sponsor Role collaborator

Assistance Publique - Hôpitaux de Paris

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Marine LIVROZET

Role: PRINCIPAL_INVESTIGATOR

Assistance Publique - Hôpitaux de Paris

Locations

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Georges-Pompidou European Hospital, AP-HP

Paris, , France

Site Status

Countries

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France

Central Contacts

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Maxime BRUSSIEUX

Role: CONTACT

+33 1 44 84 17 89

Laura LE MAO

Role: CONTACT

+33 1 56 09 54 97

Facility Contacts

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Marine Livrozet

Role: primary

Other Identifiers

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PRTS-21-0009

Identifier Type: OTHER_GRANT

Identifier Source: secondary_id

APHP211383

Identifier Type: -

Identifier Source: org_study_id

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