Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease

NCT ID: NCT00610597

Last Updated: 2008-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

49 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-01-31

Study Completion Date

2008-01-31

Brief Summary

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Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.

Detailed Description

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Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.

Conditions

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Alcoholic Liver Disease Chronic Hepatitis C Virus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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1

alcoholic liver disease

No interventions assigned to this group

2

chronic hepatitis C virus infection

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Alcohol excess intake and suspected liver disease
* Alcohol excess intake and clinical liver cirrhosis
* chronic hepatitis C virus infection and suspected liver disease
* chronic hepatitis C virus infection and clinical liver cirrhosis

Exclusion Criteria

* bacterial or fungal infection
* immunosuppressive treatment
* other causes of liver disease
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Erasme University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Erasme University Hospital

Principal Investigators

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Arnaud Lemmers, MD

Role: PRINCIPAL_INVESTIGATOR

Erasme Hospital, Gastroenterology Dpt

Locations

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Hopital Erasme - Dpt of Gastroenterology

Brussels, , Belgium

Site Status

Countries

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Belgium

References

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Lemmers A, Moreno C, Gustot T, Marechal R, Degre D, Demetter P, de Nadai P, Geerts A, Quertinmont E, Vercruysse V, Le Moine O, Deviere J. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology. 2009 Feb;49(2):646-57. doi: 10.1002/hep.22680.

Reference Type DERIVED
PMID: 19177575 (View on PubMed)

Other Identifiers

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AL-ALD

Identifier Type: -

Identifier Source: secondary_id

AL-ALD

Identifier Type: -

Identifier Source: org_study_id

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