Role of CCL2 in Alcoholic Liver Diseases

NCT ID: NCT01128010

Last Updated: 2010-05-21

Basic Information

• Recruitment Status: COMPLETED
• Study Classification: OBSERVATIONAL

Brief Summary

Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.

Conditions

Alcoholic Liver Disease

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

alcoholic liver disease

alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution

No interventions assigned to this group

controls

Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Excess alcohol intake
• Abnormality of liver biopsy compatible with alcoholic aetiology
• Caucasian ethnicity

• Caucasian ethnicity
• presence of a disease

Exclusion Criteria

• Presence of any other chronic liver disease

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Erasme University Hospital

OTHER

Sponsor Role: lead

Other Identifiers

DD-CCL2

Identifier Type: -

Identifier Source: org_study_id