Endoscopic Sphincterotomy vs. Balloon Dilation for Assessment of Pancreatitis

NCT ID: NCT02346448

Last Updated: 2019-02-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

600 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-28

Study Completion Date

2020-12-31

Brief Summary

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One of the major elements of successful endoscopic retrograde cholangiopancreatography ( ERCP) is the timely and uncomplicated cannulation of the common bile duct (CBD) . Various factors may adversely affect the cannulation procedure of the CBD leading to complications (acute pancreatitis after ERCP, perforation of the duodenum , bleeding ). Endoscopic sphincterotomy is frequently required for interventional procedures (eg stone extraction). During sphincterotomy, incision of the orifice of the papilla will be performed by using a sphincterotome. Complications due to sphincterotomy are known: Bleeding, increased rates of acute pancreatitis, small bowel perforation and scarring with consecutive stenosis of the papilla. As an alternative to sphincterotomy, balloon dilatation using balloon catheters can be performed. As a result, bleeding complications and scarring as late effects might be prevented. Current data is limited in terms of the risk of acute pancreatitis after ERCP when using a balloon catheter.

This study aims to evaluate the incidence of acute pancreatitis and other complications after ERCP. Balloon dilatation of the papilla will be prospectively compared with endoscopic sphincterotomy in a randomized multicenter setting.

Detailed Description

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Conditions

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Pancreatitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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endoscopic sphincterotomy

performing endoscopic sphincterotomy of papilla of Vater during ERCP Device: standard sphincterotome

Group Type ACTIVE_COMPARATOR

endoscopic sphincterotomy

Intervention Type PROCEDURE

sphincterotomy during ERCP

balloon dilatation for 3 minutes

Balloon dilatation of papilla of Vater for 3 minutes during ERCP using 10mm balloon Device: standard dilation balloon catheter (10mm size)

Group Type ACTIVE_COMPARATOR

balloon dilatation for 3 minutes

Intervention Type PROCEDURE

balloon dilatation during ERCP using 10mm balloon

balloon dilatation for 6 minutes

Balloon dilatation of papilla of Vater for 6 minutes during ERCP using 10mm balloon Device: standard dilation balloon catheter (10 mm size)

Group Type ACTIVE_COMPARATOR

balloon dilatation for 6 minutes

Intervention Type PROCEDURE

balloon dilatation during ERCP using 10mm balloon

Interventions

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endoscopic sphincterotomy

sphincterotomy during ERCP

Intervention Type PROCEDURE

balloon dilatation for 3 minutes

balloon dilatation during ERCP using 10mm balloon

Intervention Type PROCEDURE

balloon dilatation for 6 minutes

balloon dilatation during ERCP using 10mm balloon

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* independent indication for ERCP
* age ≥ 18 years
* patient is able to understand informed consent

Exclusion Criteria

* S/p sphincterotomy
* pancreatic or CBD-stent in situ
* pregnant patient
* known chronic pancreatitis
* acute pancreatitis prior to intervention
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Helios Albert-Schweitzer-Klinik Northeim

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Tobias Meister, PDDr.med.

Role: STUDY_DIRECTOR

Helios Albert-Schweitzer-Hospital

Volker Ellenrieder, ProfDr.med.

Role: STUDY_DIRECTOR

University Medical Center Göttingen

Locations

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Department of Gastroenterology, University Medical Center

Göttingen, Lower Saxony, Germany

Site Status RECRUITING

HELIOS Albert-Schweitzer Hospital Northeim

Northeim, Lower Saxony, Germany

Site Status RECRUITING

HELIOS Klinikum Erfurt

Erfurt, Thuringia, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Tobias Meister, PDDr.med.

Role: CONTACT

+495551971244

Facility Contacts

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Volker Ellenrieder, Professor

Role: primary

+49551390

Tobias Meister, PDDr.med.

Role: primary

+495551971244

Jens Scharf, Professor

Role: primary

Role: backup

+49361 7810

Other Identifiers

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HELIOS 4/8/14

Identifier Type: -

Identifier Source: org_study_id

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