Individual Phenotype Analysis in Patients With Castration-Resistant Prostate Cancer With CellSearch® and Flow Cytometry

NCT ID: NCT02282644

Last Updated: 2018-02-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-09-08

Study Completion Date

2017-08-25

Brief Summary

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The recent data suggest that cancer cells at the origin of prostate cancer metastases can be detected in an early stage. Available techniques allow phenotypic analysis of cancer cells in circulating blood (cellsearch) or in marrow hematopoietic (flow cytometry). Pilot study on 180 patients infected by prostate cancer at all stage of disease, show that c-met marker , integrin alpha 2 and 6 expressed in marrow and quantified by flow cytometry were predictor of metastatic progress. In this new study the investigators will analyze antibody panel by cellsearch and flow cytometry on marrow sample of castration-Resistant prostate cancer patients.

Detailed Description

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Conditions

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Prostate Cancer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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CellSearch

Group Type EXPERIMENTAL

Bone marrow sampling

Intervention Type BIOLOGICAL

Interventions

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Bone marrow sampling

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* Histologically confirmed adenocarcinoma or prostate
* Ongoing effective androgen deprivation therapy (testosterone ≤ 50 ng/mL)
* Castration-Resistant prostate cancer patient : defined as a minimum of 3 rising PSA values assessed and/or radiological progress confirmed by RECIST and PCWG2
* Patient who signed informed consent

Exclusion Criteria

* Severe disorders of coagulation
* Major skin lesion on iliac crests
* Allergies in local anesthetics
* Psychological instability or psychiatric histories
* Uncertain follow-up and distant residence
* History of another invasive cancer and hematologic disease
* Patient deprived of their freedom by court or administrative order
* Revocation of consent
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hôpital Edouard Herriot - service d'urologie

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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2013.824

Identifier Type: -

Identifier Source: org_study_id

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