Circulating And Intra-Tumoral Chemokines In Patients With Prostate Cancer

NCT ID: NCT02869282

Last Updated: 2025-09-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2011-06-30

Study Completion Date

2016-12-31

Brief Summary

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Multicentric, observational, prospective, non-interventional study with occasional biological sample collection (serum bank, urine bank and tumor bank)

Detailed Description

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This project is an exploratory study, based on the hypothesis of involvement of chemokines in hormonal escape of prostate cancers.

The two main objectives are:

* To describe the variations in expression of chemokines in serum and urine level in patients with prostate cancer
* And to study the disease stage and intra-prostatic concentrations of chemokines based on serum and urine concentrations of chemokines before treatment initiation.

These estimates can be used in future trials set up for the management of prostate cancer

Conditions

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Prostate Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Prospective cohort

Levels of CXCL1, CCL5, CXCL8 and CXCL12 chemokines and of IL-6 cytokine by ELISA or Luminex technology.

Blood samples

Intervention Type OTHER

Additional blood samples at baseline, 6, 12, 18 and 24 months.

Urine samples

Intervention Type OTHER

Additional urine samples at baseline, 6, 12, 18 and 24 months.

Interventions

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Blood samples

Additional blood samples at baseline, 6, 12, 18 and 24 months.

Intervention Type OTHER

Urine samples

Additional urine samples at baseline, 6, 12, 18 and 24 months.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients with a localized or metastatic prostate adenocarcinoma for which a new treatment will be implemented (hormone therapy for single biological relapse or relapses and metastatic hormone-sensitive) or chemotherapy (for biological relapses and / or metastatic hormone-resistant)
* Patients with a detectable PSA (Prostate-Specific Antigen)
* Patients who signed an informed consent
* Patients over 18 years
* Patients belonging to the social security scheme

Exclusion Criteria

* Active Hepatitis B or C virus
* HIV positive
* Patients who have received prior chemotherapy
* Patients with a second neoplasia treated in the last 5 years
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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Institut Bergonié

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Institut Bergonié

Bordeaux, , France

Site Status

Countries

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France

Other Identifiers

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IB2011-CHEMOPROST

Identifier Type: -

Identifier Source: org_study_id

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