Study Results
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Basic Information
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COMPLETED
EARLY_PHASE1
10 participants
INTERVENTIONAL
2014-10-31
2015-05-31
Brief Summary
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In this study, the investigators will therefore examine the effect of a single dose of intranasal oxytocin (compared to placebo) on levels of appetite-regulating hormones and functional magnetic resonance imaging activation of areas of the brain involved in food motivation.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
TRIPLE
Study Groups
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Oxytocin
Oxytocin 24 IU x 1
Oxytocin
Single dose, intranasal
Placebo
Placebo 24 IU x 1
Placebo
Single dose, intranasal
Interventions
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Oxytocin
Single dose, intranasal
Placebo
Single dose, intranasal
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* BMI 25-40
* Regular breakfast eater (at least 4 times per week)
* Stable weight within the past three months
Exclusion Criteria
* History of eating disorder
* History of excessive exercise within the last three months (having run more that 25 miles in any one week or having exercised more than ten hours in any one week)
* History of diabetes mellitus
* Active substance abuse
* Hematocrit lower than the normal range
* Gastrointestinal tract surgery (including gastrectomy, gastric bypass surgery, and small or large bowel resection)
* History of cardiovascular disease (such as hypertrophic cardiomyopathy, valvular heart disease, coronary heart disease, or coronary artery spasms)
* Untreated thyroid disease
* Tobacco use
* Cardiac pacemaker, surgical aneurysm clips, neurostimulator, implanted pumps, metal fragments in body/eyes, nitroglycerin patch, severe claustrophobia
18 Years
45 Years
MALE
Yes
Sponsors
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Massachusetts General Hospital
OTHER
Responsible Party
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Elizabeth Austen Lawson
Assistant Professor of Medicine, Harvard Medical School
Principal Investigators
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Elizabeth A Lawson, MD, MMSc
Role: PRINCIPAL_INVESTIGATOR
Massachusetts General Hospital
Locations
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Massachusetts General Hospital
Boston, Massachusetts, United States
Countries
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Other Identifiers
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SPID 1127
Identifier Type: -
Identifier Source: org_study_id
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