Enhanced Diagnostics for Early Detection of Atrial Fibrillation

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

287 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2015-10-31

Brief Summary

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Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present.

The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.

Detailed Description

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In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens.

Parameters tested are

1. Electrophysiological differences between patients with paroxysmal AF and no history of AF
2. "Vascular Stiffness" detected by an iPhone app

All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.

Conditions

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Atrial Fibrillation

Keywords

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atrial fibrillation atrial electrophysiology stroke vascular stiffness

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Paroxysmal Af

No Intervention is planned. All patients receive a 5 Minute ECG and have their pulse recordes by an iPhone.

ECG

Intervention Type DEVICE

Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.

Interventions

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ECG

Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* paroxysmal atrial fibrillation in sinus rhythm at presentation

Exclusion Criteria

* acute cerebral trauma
* antiarrhythmic medication

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Jens Eckstein

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jens Eckstein, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Universityhospital Basel

Locations

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University Hospital Basel

Basel, Canton of Basel-City, Switzerland

Site Status

Countries

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Switzerland

References

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Brasier N, Engelter S, Kolbitsch T, Tabord A, Knobeloch J, Kuhne M, Conen D, Traenka C, Kreutzberger T, Vollmin G, Eckstein J. The quest for indicators of paroxysmal atrial fibrillation in sinus rhythm - the DETECT AF trial. Acta Cardiol. 2019 Aug;74(4):301-307. doi: 10.1080/00015385.2018.1493248. Epub 2018 Aug 19.

Reference Type DERIVED

PMID: 30122130 (View on PubMed)

Other Identifiers

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EKNZ:2014-080

Identifier Type: -

Identifier Source: org_study_id