Legume Diet Satiety Pilot Study

NCT ID: NCT02269631

Last Updated: 2019-01-25

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-12-31

Study Completion Date

2017-12-31

Brief Summary

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This pilot study is designed to test the effects of a high legume (dried bean) diet on hunger and other indicators of health over the course of eight weeks, compared to a more conventional healthy diet.

Detailed Description

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The goal of the currently proposed study is to conduct a randomized controlled feeding pilot study within a more diverse population also at high risk for colorectal carcinoma (CRC) to evaluate whether a high-legume diet will result in increased satiety and in turn will facilitate reduced energy intake and weight loss compared to a control diet provided under similar conditions. In addition, explore potential beneficial effects of the high-legume diet on gastric emptying and circulating levels of appetite-regulating hormones and other biomarkers. Dietary behaviors that are even moderately more satiating over time have the potential to enhance weight loss and could lead to a significant public health impact among populations at high risk for colorectal carcinoma (CRC) and other chronic diseases.

Towards the end of the study, the participants will do an additional test, looking at how long food takes to pass through the digestive system using a SmartPill capsule. The SmartPill is a pill about the size of a large multivitamin that can measure pH, pressure, and temperature changes, which it uses to assess where in the digestive tract it is. The participant swallows the pill, and carries around a receiver that is about the size of a deck of cards for the next 3-5 days. The SmartPill is expelled, and the receiver notifies the participant that they can return the receiver to the study personnel.

Conditions

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Obesity Colorectal Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Investigators

Study Groups

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Legume diet group

Meals will include approximately 1 ½ cups of cooked legumes, such as pinto, baked and navy beans as part of your 2 daily main dishes (lunch and dinner) and additional foods and snacks, preferably from the recommended healthy foods list. The smartpill will be administered at the end of the study.

Group Type EXPERIMENTAL

Legume diet group

Intervention Type BEHAVIORAL

about 1 1/2 cups of legumes included in lunch and dinner meals

Smartpill

Intervention Type DEVICE

to assess how long food takes to pass through the digestive system

legumes

Intervention Type OTHER

about 1 1/2 cups of legumes included in lunch and dinner meals

Control diet group

Meals will be healthy, typical American foods (without legumes) for 2 daily main dishes and additional foods and snacks, preferably from the recommended healthy foods list.The smartpill will be administered at the end of the study.

Group Type ACTIVE_COMPARATOR

Control diet group

Intervention Type BEHAVIORAL

no legumes in lunch or dinner meals

Smartpill

Intervention Type DEVICE

to assess how long food takes to pass through the digestive system

Interventions

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Legume diet group

about 1 1/2 cups of legumes included in lunch and dinner meals

Intervention Type BEHAVIORAL

Control diet group

no legumes in lunch or dinner meals

Intervention Type BEHAVIORAL

Smartpill

to assess how long food takes to pass through the digestive system

Intervention Type DEVICE

legumes

about 1 1/2 cups of legumes included in lunch and dinner meals

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI overweight-obese: 25.0-40 kg/m2
* Colonoscopy within the last two years that found ≥1 adenoma
* English speaking
* Ambulatory, able to come to either food distribution site to pick up food and participate in clinical examinations and laboratory tests

Exclusion Criteria

* Serious medical condition (e.g., cancer, heart disease, kidney disease, diabetes)
* History of CRC, bowel resection, polyposis syndrome, or inflammatory bowel disease
* Smoked regularly in the past year
* Dietary restrictions substantially limiting compliance or vegetarian or Vegan diet
* Planning on changing diet or exercise behavior in the next 6 months
* Regular use of medication that may alter inflammation markers, insulin, glucose, or gut function (i.e. regular use of non-steroidal anti-inflammatory medication, insulin therapy, steroid therapy, or antibiotics)
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Emory University

OTHER

Sponsor Role lead

Responsible Party

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Terry Hartman

Terry Hartman PhD, MPH, RD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Terry J Hartman, PhD, MPH, RD

Role: PRINCIPAL_INVESTIGATOR

Rollins School of Public Health, Emory University

Locations

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Morehouse

Atlanta, Georgia, United States

Site Status

Emory ACTSI

Atlanta, Georgia, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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IRB00075830

Identifier Type: -

Identifier Source: org_study_id

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