Red Blood Cells as a Reflection of Endothelial Function in Old Age

NCT ID: NCT02265003

Last Updated: 2021-02-16

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 140 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2012-07-31
• Study Completion Date: 2020-12-31

Brief Summary

The aim of this study is to find out, how far red blood cells reflect age-depended changes in endothelial function.

Detailed Description

It will be investigated with determination of endothelial function (measured as flow-mediated vasodilation) and of circulated nitric oxid-pool in red blood cells and in blood plasma, how far red blood cells reflect age-depended changes in endothelial function.

Conditions

Red Blood Cells; Endothelial Function; Nitric Oxide Pool in Red Blood Cells and Blood Plasma

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Healthy young age

Healthy subjects in age of 18-35 years, without cardiac dysrhythmia, hypertension, diabetes mellitus, acute inflammations and terminal kidney disease

No interventions assigned to this group

Healthy middle age

Healthy subjects in age of 35-45 years, without cardiac dysrhythmia, hypertension, diabetes mellitus, acute inflammations and terminal kidney disease

No interventions assigned to this group

Healthy old

Healthy subjects in age of \>70 years, without cardiac dysrhythmia, hypertension, diabetes mellitus, acute inflammations and terminal kidney disease

No interventions assigned to this group

Patients

Patients with atherosclerosis

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• healthy subjects
• informed consent

• angiographical signs of apparent atherosclerosis (cardiac artery disease or peripheral vascular disease or degenerative valvular heart disease)
• informed consent

Exclusion Criteria

• hypertension (blood pressure ≥140/90 mmHg),
• hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
• diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
• acute inflammation (CRP >0.5 mg/dl)
• malignant diseases
• heart failure (NYHA III-IV)
• arrhythmia of high degree
• acute or terminated kidney disease
• cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
• anemia
• pregnancy

Group 4 :

• Hypertension (blood pressure ≥140/90 mmHg),
• Hypercholesterolemia (LDL ≥250 mg/dl, HDL ≤45 mg/dl),
• Diabetes mellitus (fasting plasma glucose ≥128 mg/dl)
• acute inflammation (CRP >0.5 mg/dl)
• malignant diseases
• heart failure (NYHA III-IV)
• arrhythmia of high degree
• acute or terminated kidney disease
• cardiovascular diseases ( cardiac artery disease, peripheral vascular disease and cerebrovascular diseases)
• anemia
• pregnancy

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Heinrich-Heine University, Duesseldorf

OTHER

Sponsor Role: lead

Responsible Party

Klinik für Kardiologie, Pneumologie und Angiologie

Principle Investigator Prof. Dr. Malte Kelm

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Malte Kelm, Prof. MD

Role: PRINCIPAL_INVESTIGATOR

Department of Cardiology, Pneumology and Angiology, University Hospital Duesseldorf

Locations

University Hospital Duesseldorf

Düsseldorf, , Germany

Countries

Germany

Other Identifiers

14-016

Identifier Type: OTHER

Identifier Source: secondary_id

Anaemie

Identifier Type: -

Identifier Source: org_study_id