Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction

NCT ID: NCT04998227

Last Updated: 2024-04-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-26

Study Completion Date

2025-03-01

Brief Summary

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The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).

Detailed Description

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The investigators will collect the blood samples from patients with suspect ACS. LTBP4 will be the first matrix protein that are going to understand. Upon hospital arrival, blood samples around 8 ml will be collected and the 2nd collection will be two weeks to one month after the event. The third collection will be one year later. In the between, if any ACS event develop, blood samples will be collected as protocols.

Conditions

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Acute Coronary Syndrome Acute Coronary Syndrome With Renal Dysfunction

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Study Groups

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suspect acute coronary syndrome

Subjects with the diagnosis of suspected acute coronary syndrome (ACS), age between 20 to 80.

Exclusion criteria: pregnant women, patients with end-stage renal disease (eGFR \<15 mL/min/1.73 m2), cardiogenic shock.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

\- acute coronary syndrome patients

Exclusion Criteria

\- cardiogenic shock, pregnancy, end-stage renal disease
Minimum Eligible Age

20 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Chi-Ting Su, MD. MPH, PhD

Role: CONTACT

+886972652878

Yue-Jhu Huang, MS

Role: CONTACT

+886912282113

Facility Contacts

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Chi-Ting Su, MD, MPH, PhD

Role: primary

Other Identifiers

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202103008RINB

Identifier Type: -

Identifier Source: org_study_id

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