Analysis of Proteome and Pathophysiological Characteristics of Human Blood Cells

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-07-31

Study Completion Date

2020-12-31

Brief Summary

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The aim of this study is to investigate wether change in endothelial nitric oxid synthase of blood cells (erythrocytes and peripheral blood mononuclear cells (PBMC)) has an influence on development and progression of cardiovascular diseases.

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Detailed Description

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Conditions

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Red Blood Cell Peripheral Blood Mononuclear Cell Endothelial NO-synthase

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Healthy

100 healthy volunteers in age of 20-75 years

No interventions assigned to this group

Patients

100 patients with stable coronary artery disease and accordingly endothelial dysfunction

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* healthy volunteers
* Patients: stable coronary artery disease with accordingly endothelial dysfunction

Exclusion Criteria

* acute inflammation (CRP\>0,5 mg/dl, leucocyte \>11000/dl)
* malignant diseases
* acute or terminated kidney disease
* relevant heart failure (NYHA III-IV)

Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes