Genetic Polymorphisms of TNF-α Promoter and HBV Genotype on Outcome of HBV-Related Chronic Liver Disease

NCT ID: NCT00629668

Last Updated: 2008-03-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2007-12-31

Brief Summary

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The prognosis of Hepatitis B virus (HBV)infection varies from minimal progressive liver disease to cirrhosis or hepatocellular carcinoma (HCC).Both viral and host genetic factors contribute to disease severity. Cytokine gene polymorphism has been regarded affecting prognosis of disease. By detecting HBV genotyping and tumor necrosis factor-alpha polymorphism, this study aime to assess their effects and interaction on disease severity of HBV-related chronic liver disease and HCC.

Detailed Description

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Conditions

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Chronic Liver Disease Hepatocellular Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Interventions

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TNF-alpha and HBV genotype

Intervention Type GENETIC

TNF-alpha and HBV genotypes

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* HBV-positive patients

Exclusion Criteria

* HBV-negative patients
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Kaohsiung Medical University Chung-Ho Memorial Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Jen-Eing Jeng, M.D.

Role: PRINCIPAL_INVESTIGATOR

Assistant Professor of Clinical Laboratory

Locations

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Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, Kaohsiung, Taiwan

Site Status RECRUITING

Countries

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Taiwan

Facility Contacts

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Jen-Eing Jeng, M.D.

Role: primary

886-7-3121101 ext. 7223

Other Identifiers

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KMUH-IRB-940189

Identifier Type: -

Identifier Source: org_study_id

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