DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis

NCT ID: NCT02252653

Last Updated: 2016-07-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1010 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-06-30

Study Completion Date

2016-03-31

Brief Summary

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The purpose of this study is to characterize the frequency of TTR mutations in subjects suspected of having cardiac amyloidosis

Detailed Description

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Conditions

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Familial Amyloidotic Cardiomyopathy (FAC)

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Familial Amyloidotic Cardiomyopathy (FAC)

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Males or females \>18 years old
* History of evidence suggestive of cardiac amyloidosis
* Subject is willing and able to comply with protocol required assessments and provide written informed consent

Exclusion Criteria

* Known diagnosis of primary (AL) amyloidosis
* Known diagnosis of hereditary cardiomyopathy or cardiomyopathy due to aortic stenosis
* Patient is currently pregnant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alnylam Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jared Gollob, MD

Role: STUDY_DIRECTOR

Alnylam Pharmaceuticals

Locations

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Little Rock, Arkansas, United States

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Bakersfield, California, United States

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La Mesa, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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San Francisco, California, United States

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Torrance, California, United States

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Aurora, Colorado, United States

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Washington D.C., District of Columbia, United States

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Washington D.C., District of Columbia, United States

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Washington D.C., District of Columbia, United States

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Tampa, Florida, United States

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Athens, Georgia, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Macon, Georgia, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Merrillville, Indiana, United States

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Baltimore, Maryland, United States

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Boston, Massachusetts, United States

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Springfield, Massachusetts, United States

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Detroit, Michigan, United States

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Jackson, Mississippi, United States

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St Louis, Missouri, United States

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Camden, New Jersey, United States

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Rochester, New York, United States

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Rosedale, New York, United States

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The Bronx, New York, United States

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Williamsville, New York, United States

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Durham, North Carolina, United States

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Cleveland, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Charleston, South Carolina, United States

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Fort Worth, Texas, United States

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Plano, Texas, United States

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Falls Church, Virginia, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Anderlecht, , Belgium

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Brussels, , Belgium

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Hasselt, , Belgium

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Roeselare, , Belgium

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Blumenau, , Brazil

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Bordeaux, , France

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Toulouse, , France

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Vandœuvre-lès-Nancy, , France

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Barcelona, , Spain

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Barcelona, , Spain

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Madrid, , Spain

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Seville, , Spain

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Cardiff, , United Kingdom

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London, , United Kingdom

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London, , United Kingdom

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Countries

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United States Belgium Brazil France Spain United Kingdom

Other Identifiers

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ALN-TTR-NT-002

Identifier Type: -

Identifier Source: org_study_id

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