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Calcium Channel Splice Variant Expression in Cardiovascular Disease and Aging

NCT ID: NCT00251615

Last Updated: 2012-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

18 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-08-31

Study Completion Date

2012-08-31

Brief Summary

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The purpose of this study is to learn what changes in blood vessel contraction may occur as a result of a disease of the vessel that requires surgery. The study will examine the calcium channels present in the vessels being operated on, and the genes that may alter blood vessel function. Possible variation in these genes may change the kind of calcium channels present in blood vessels.

Detailed Description

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The goal of this study is to learn more about how blood vessels function and the mechanism that causes them to contract. The study will investigate the natural history of diseased blood vessel tissue and the calcium channels in the muscle part of the blood vessel. The study will also examine how genetics influences cardiovascular disease and its causes and treatments.

Patients scheduled for vascular surgery will be approached to participate in this study. During surgery, tissue fragments of diseased and marginal tissue will be obtained. A blood sample will be obtained at either the time of surgery or consent and genomic DNA will be extracted.

Conditions

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Atherosclerosis

Keywords

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vascular surgery vascular aging arterial aging surgical tissue Aging

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* Ages 21 and older
* Scheduled for vascular surgery

Exclusion Criteria

* Unwillingness to be subjected to diagnostic and/or therapeutic procedures that are deemed not necessary for clinical management
* Volunteers deemed too fragile to participate in the study by the principal investigator (PI) or the attending physician
* Inability to obtain informed consent from either the volunteer or the responsible party (durable power of attorney \[DPA\]) for the volunteer, with the volunteer's assent
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Samer Najjar, MD

Role: PRINCIPAL_INVESTIGATOR

National Institute on Aging (NIA)

Locations

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National Institute on Aging, Harbor Hospital

Baltimore, Maryland, United States

Site Status

Countries

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United States

References

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Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM. New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem. 2004 Nov 5;279(45):46367-72. doi: 10.1074/jbc.M409523200. Epub 2004 Aug 31.

Reference Type BACKGROUND
PMID: 15339916 (View on PubMed)

Kobrinsky E, Tiwari S, Maltsev VA, Harry JB, Lakatta E, Abernethy DR, Soldatov NM. Differential role of the alpha1C subunit tails in regulation of the Cav1.2 channel by membrane potential, beta subunits, and Ca2+ ions. J Biol Chem. 2005 Apr 1;280(13):12474-85. doi: 10.1074/jbc.M412140200. Epub 2005 Jan 25.

Reference Type BACKGROUND
PMID: 15671035 (View on PubMed)

Abernethy DR, Soldatov NM. Structure-functional diversity of human L-type Ca2+ channel: perspectives for new pharmacological targets. J Pharmacol Exp Ther. 2002 Mar;300(3):724-8. doi: 10.1124/jpet.300.3.724.

Reference Type BACKGROUND
PMID: 11861774 (View on PubMed)

Other Identifiers

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AG0058

Identifier Type: -

Identifier Source: org_study_id