Relationship of Essential Hypertension and Its Treatments on the Postoperative Pain Management: a Prospective, Observational, Cross-sectional Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-11-30

Brief Summary

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Numbers of postoperative PCA related side effects among three groups will be determined by comparing and analyzing frequency distributions. To determine whether the patients with hypertension require less post operative opiate analgesics than others, multivariate analysis with repeated measures will be performed to identify the major and the minor factors predicting the use of postoperative pain therapy. The major aim of the study is to test the hypothesis that the morphine comsumpted by the hypertension group is less than those of the normotension group. The minor aims for the study are the difference related to pain intensity, or the incidence of side effects among groups.

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Detailed Description

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Conditions

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Hypertension

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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normotension group

Until 11,March, 2015, 31 cases are collected.

No interventions assigned to this group

hypertension group without treatment

Until 11,March, 2015, 60 cases are collected.

No interventions assigned to this group

hypertension group with antihypertensive treatment

(ACEI, beta-blocker, Ca blocker, Diuretics) prior to the surgery.

Until 11,March, 2015, 59 cases are collected.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* 300 eligible subjects
* No contraindication for inhalation anesthesia
* Elective surgery
* Age between 20-75 y/o
* No contraindication for postoperative morphine pain control
* Female or male
* Essential hypertension stage I and II (140\<=SBP\<=180; 90\<=DBP\<=110)

Exclusion Criteria

* Liver disease
* Renal disease
* Those who is presumed to go to ICU after surgery
* The patients with dementia or conscious disturbance
* Pregnancy or breast feeding
* Secondary hypertension
* events in recent 6 months myocardial infarction cardiac bypass surgery unstable angina cerebrovascular events congestive heart failure significant arrhythmia thoracic surgery

Minimum Eligible Age

20 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes