Effects Of Native Collagen Type 2 Treatment

NCT ID: NCT02237989

Last Updated: 2020-09-18

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

39 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-01-31

Study Completion Date

2013-12-31

Brief Summary

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The aim of this study was to evaluate symptomatic efficacy of native collagen type 2 on joint pain and function and its effects on urinary biological markers related to cartilage degeneration in patients with knee osteoarthritis.

Detailed Description

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39 patients diagnosed with knee osteoarthritis were separated into two groups. The 1st group includes 19 patients given 1500mg/day paracetamol, the 2nd group consists of 20 patients given 1500mg/day paracetamol and 10mg/day native collagen type 2 for three months.Pretreatment and posttreatment Visual Analog Scale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), 20-m walking time and Short Form-36 (SF-36), Coll2-1, Coll2-1NO2 and Fibulin-3 levels in urine were compared.

Conditions

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Knee Osteoarthritis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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paracetamol

The 1st group includes 19 patients given 1500mg/day paracetamol for three months

Group Type ACTIVE_COMPARATOR

paracetamol

Intervention Type DRUG

1500 mg

native collagen type 2 + paracetamol

The 2nd group consists of 20 patients given 1500mg/day paracetamol and 10mg/day native collagen type 2 for three months

Group Type EXPERIMENTAL

paracetamol+native collagen type 2

Intervention Type DRUG

paracetamol (1500 mg) + native collagen type 2 (10mg)

Interventions

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paracetamol

1500 mg

Intervention Type DRUG

paracetamol+native collagen type 2

paracetamol (1500 mg) + native collagen type 2 (10mg)

Intervention Type DRUG

Eligibility Criteria

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Exclusion Criteria

\-
Minimum Eligible Age

45 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eskisehir Osmangazi University

OTHER

Sponsor Role lead

Responsible Party

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Onur Armağan

Onur Armagan, Medical Doctor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Fulya Bakilan, Specialist

Role: STUDY_DIRECTOR

Yerkoy State Hospital

References

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Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O. Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial. Eurasian J Med. 2016 Jun;48(2):95-101. doi: 10.5152/eurasianjmed.2015.15030.

Reference Type DERIVED
PMID: 27551171 (View on PubMed)

Other Identifiers

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FY2001

Identifier Type: -

Identifier Source: org_study_id

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