Serum Nesfatin-1 and Human Cartilage Glycoprotein-39 Levels in Knee Osteoarthritis
NCT ID: NCT06254976
Last Updated: 2024-02-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2022-06-01
2023-12-01
Brief Summary
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Detailed Description
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Thirty patients diagnosed with grade 2 and 3 knee osteoarthritis (OA) according to American College of Rheumatology (ACR) diagnostic criteria, and scheduled for leukocyte-poor platelet-rich plasma (LP-PRP) injections, were enrolled in the study. Patients were assessed at three time points: before treatment (day 0), after exercise treatment (day 14), and after two doses of LP-PRP treatment combined with exercise treatment once a week (day 28). The evaluation included the Numeric Rating Scale (NRS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), cartilage thickness measurement by ultrasonography (USG), 6-minute walk test (6MWT) parameters, and measurements of serum YKL-40 and nesfatin-1 levels.
Conditions
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Study Design
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NON_RANDOMIZED
SEQUENTIAL
TREATMENT
SINGLE
Study Groups
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2 week home exercise program
Joint range of motion exercises, four-way straight leg raises, isotonic quadriceps strengthening, hamstring and quadriceps stretching exercises were given. The exercise program was demonstrated by the same physiotherapist. The patients' exercise compliance was questioned and noted.
exercise
2 weeks of home exercise
2 doses of intraarticular PRP application, 1 week apart
2 doses of intra-articular 3 cc LP-PRP were applied to the patients, 1 week apart, from the inferolateral aspect of the patella, in accordance with antisepsis conditions, by a physical medicine and rehabilitation specialist.
intraarticular knee PRP injections
2 doses of intra-articular platelet rich plasma (PRP) injection, 1 week apart
Interventions
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exercise
2 weeks of home exercise
intraarticular knee PRP injections
2 doses of intra-articular platelet rich plasma (PRP) injection, 1 week apart
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Having stage 2-3 knee osteoarthritis according to the Kellgren-Lawrence scale,
* Being diagnosed with knee osteoarthritis according to ACR (American college of Rheumatology),
* Being over the age of 18 - under the age of 75,
* Having NRS 4 and above
Exclusion Criteria
* Those who have had any local injections such as physical therapy, intra-articular steroid or hyaluronic acid injection in the knee area in the last 3 months,
* Malignancies,
* Those with local infection, wound, scar in the relevant area,
* Infections, Hepatitis, Immunosuppression,
* Inflammatory arthropathies,
* Uncontrolled Hypertension, uncontrolled Diabetes Mellitus, decompensated heart failure, coronary artery disease, asthma
* Recent trauma,
* Epileptic patients,
* Pregnant women,
* Corticosteroid use,
* Avascular necrosis
* Anemia, bleeding coagulation disorder
18 Years
75 Years
ALL
No
Sponsors
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Kayseri City Hospital
OTHER_GOV
Responsible Party
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Havva Talay Çalış
professor doctor
Principal Investigators
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Havva Talay Çalış, Prof
Role: STUDY_DIRECTOR
Saglik Bilimleri Universitesi
Duygu Gökbelen Bilen
Role: PRINCIPAL_INVESTIGATOR
Saglik Bilimleri Universitesi
Locations
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Health Sciences University, Kayseri Medicine Faculty, Kayseri City Hospital
Kayseri, , Turkey (Türkiye)
Countries
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Other Identifiers
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health sciences university
Identifier Type: -
Identifier Source: org_study_id
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