Nighttime Protein Intake on Overnight Lipolysis and Morning Fat Oxidation in Obese Men

NCT ID: NCT02211391

Last Updated: 2015-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2015-08-31

Brief Summary

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Single macronutrients will be consumed before sleep by obese men. Overnight lipolysis will be measured with the microdialysis technique by measuring glycerol concentration and blood flow in abdominal adipose tissue. Morning fat oxidation will be measured with indirect calorimetry.

The investigators hypothesize that carbohydrate intake will blunt the overnight lipolysis rate compared to casein protein and a non-caloric placebo. The investigators also hypothesize that casein and placebo will not be significantly different from each other in terms of overnight lipolysis.

Detailed Description

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Conditions

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Obesity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Casein Protein

Casein protein (30g) will be consumed as the last food/caloric beverage and within 30 minute of sleep

Group Type EXPERIMENTAL

Casein Protein

Intervention Type OTHER

The effect of casein protein consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined

Non-caloric Placebo

The non-caloric placebo beverage will will be consumed as the last food/caloric beverage and within 30 minute of sleep

Group Type PLACEBO_COMPARATOR

Non-caloric placebo

Intervention Type OTHER

The effect of a non-caloric placebo consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined

Interventions

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Casein Protein

The effect of casein protein consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined

Intervention Type OTHER

Non-caloric placebo

The effect of a non-caloric placebo consumed within 30 minutes of sleep on overnight lipolysis and next morning metabolism and appetite will be examined

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Healthy, sedentary overweight or obese (BMI ≥25 kg/m\^2; body fat ≥ 25% ) men

Exclusion Criteria

* Men that have been exercising for more than 2 days per week for more than 45 minutes per session (within the past 6 months), have uncontrolled hypertension (Blood Pressure (BP)\>160/100 mmHg, diagnosed cardiovascular disease, stroke, diabetes, thyroid or kidney dysfunction, take cholesterol medication, or have any allergies to milk products will be excluded. Smokers will also be excluded.
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Florida State University

OTHER

Sponsor Role lead

Responsible Party

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Michael J. Ormsbee

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Michael J Ormsbee, PhD

Role: PRINCIPAL_INVESTIGATOR

Florida State University

Locations

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Institute of Sports Science and Medicine, Florida State University

Tallahassee, Florida, United States

Site Status

Countries

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United States

Other Identifiers

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HSC# 2014.13509

Identifier Type: -

Identifier Source: org_study_id

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