Mechanisms and Factors Responsible for the Inhibition of Transposons During Fetal Gonad Development in Humans

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

30 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-01-29

Study Completion Date

2027-01-31

Brief Summary

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This is a single-centre study over 36 months for the inclusion of 30 patients. The selection and inclusion of patients will take place according to the criterion of Medical Termination of Pregnancy at 4 different gestational ages (8-12 weeks of gestation (WG)), 13-16 WG, 17-23 WG and 25-35 WG. The tissue analysed will principally be the gonads, other somatic tissue will also be systematically harvested in parallel (liver and psoas muscle) for control purposes. The gonads will be subjected to molecular biology analyses destined to quantify the expression of transposons and their inhibitors.

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Detailed Description

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Conditions

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Medical Termination of Pregnancy Voluntary Termination of Pregnancy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Foetus

surgical biopsies

Intervention Type OTHER

Interventions

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surgical biopsies

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Couple or mother who has provided written informed consent
* Foetus between 10 and 37 weeks of amenorrhea (WA)
* Male foetus
* Foetus obtained following medical termination of pregnancy or voluntary termination of pregnancy